Immunotherapy Using Cyclosporine, Interferon Gamma, and Interleukin-2 After High-Dose Myeloablative Chemotherapy With Autologous Stem Cell Transplantation in Treating Patients With Refractory or Relapsed Hodgkin's Lymphoma

Completed · Phase 2/Phase 3

Conditions studied: Lymphoma

In brief

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with autologous stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more cancer cells. Giving immunotherapy using cyclosporine, interferon gamma, and interleukin-2 after stem cell transplantation may help the transplanted cells make an immune response and kill any remaining cancer cells. It is not yet known whether high-dose chemotherapy followed by autologous stem cell transplantation is more effective with or without immunotherapy. PURPOSE: This randomized phase II/III trial is studying how well high-dose chemotherapy followed by autologous stem cell transplantation, cyclosporine, interferon gamma, and interleukin-2 works and compares it to high-dose chemotherapy followed by autologous stem cell transplantation only in treating patients with refractory or relapsed Hodgkin's lymphoma.

Key facts

Study ID

NCT00070187

Run by

Children's Oncology Group

People needed

24

Starts

2003-11-01

Last updated by the study team

2013-10-17

Who can join

Age: any, up to 30. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Phoenix Children's Hospital — Phoenix, Arizona, United States
• Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• Jonsson Comprehensive Cancer Center at UCLA — Los Angeles, California, United States
• Children's Hospital and Research Center - Oakland — Oakland, California, United States
• Children's Hospital of Orange County — Orange, California, United States
• Kaiser Permanente Medical Center - Oakland — Sacramento, California, United States
• Alfred I. duPont Hospital for Children — Wilmington, Delaware, United States
• Children's National Medical Center — Washington D.C., District of Columbia, United States
• University of Florida Shands Cancer Center — Gainesville, Florida, United States
• Nemours Children's Clinic — Jacksonville, Florida, United States
• University of Miami Sylvester Comprehensive Cancer Center — Miami, Florida, United States
• Miami Children's Hospital — Miami, Florida, United States
• All Children's Hospital — St. Petersburg, Florida, United States
• St. Joseph's Cancer Institute at St. Joseph's Hospital — Tampa, Florida, United States
• Kaplan Cancer Center at St. Mary's Medical Center — West Palm Beach, Florida, United States
• Emory University Hospital - Atlanta — Atlanta, Georgia, United States
• Children's Memorial Hospital - Chicago — Chicago, Illinois, United States
• Southern Illinois University School of Medicine — Springfield, Illinois, United States
• Indiana University Cancer Center — Indianapolis, Indiana, United States
• St. Vincent Indianapolis Hospital — Indianapolis, Indiana, United States
• Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center — Kansas City, Kansas, United States
• Kosair Children's Hospital — Louisville, Kentucky, United States
• Children's Hospital of New Orleans — New Orleans, Louisiana, United States
• Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore, Maryland, United States
• Comprehensive Cancer Center at University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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