Gemtuzumab Ozogamicin in Treating Young Patients With Newly Diagnosed Acute Myeloid Leukemia Undergoing Remission Induction and Intensification Therapy
Completed · Phase 2
Conditions studied: Leukemia
In brief
RATIONALE: Giving chemotherapy before a donor bone marrow transplant helps stop the growth of cancer cells. It also helps stop the patient's immune system from rejecting the donor's stem cells. Also, monoclonal antibodies, such as gemtuzumab ozogamicin, can find cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. When the healthy stem cells from a donor are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. PURPOSE: This phase II trial is studying how well gemtuzumab ozogamicin works in treating young patients who are undergoing remission induction, intensification therapy, and allogeneic bone marrow transplant for newly diagnosed acute myeloid leukemia.
Key facts
- Study ID
- NCT00070174
- Run by
- Children's Oncology Group
- People needed
- 350
- Starts
- 2003-12-01
- Expected to finish
- 2013-12-01
- Last updated by the study team
- 2014-02-20
Who can join
Age: any. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Phoenix Children's Hospital — Phoenix, Arizona, United States
- Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
- Southern California Permanente Medical Group — Downey, California, United States
- Loma Linda University Cancer Institute at Loma Linda University Medical Center — Loma Linda, California, United States
- Jonathan Jaques Children's Cancer Center at Miller Children's Hospital — Long Beach, California, United States
- Children's Hospital Los Angeles — Los Angeles, California, United States
- Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center — Los Angeles, California, United States
- Children's Hospital Central California — Madera, California, United States
- Children's Hospital and Research Center - Oakland — Oakland, California, United States
- Children's Hospital of Orange County — Orange, California, United States
- University of California Davis Cancer Center — Sacramento, California, United States
- Sutter Cancer Center — Sacramento, California, United States
- Kaiser Permanente Medical Center - Oakland — Sacramento, California, United States
- Children's Hospital and Health Center - San Diego — San Diego, California, United States
- Children's Hospital Cancer Center — Denver, Colorado, United States
- Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center — Hartford, Connecticut, United States
- Alfred I. duPont Hospital for Children — Wilmington, Delaware, United States
- Lombardi Cancer Center at Georgetown University Medical Center — Washington D.C., District of Columbia, United States
- Children's National Medical Center — Washington D.C., District of Columbia, United States
- Broward General Medical Center Cancer Center — Fort Lauderdale, Florida, United States
- Lee Cancer Care of Lee Memorial Health System — Fort Myers, Florida, United States
- University of Florida Shands Cancer Center — Gainesville, Florida, United States
- Memorial Cancer Institute at Memorial Regional Hospital — Hollywood, Florida, United States
- Nemours Children's Clinic — Jacksonville, Florida, United States
- Comprehensive Cancer Center at University of Alabama at Birmingham — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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