Celecoxib in Treating Postmenopausal Women Who Are Undergoing Surgery for Invasive Breast Cancer

Completed · Phase 1

Conditions studied: Stage I Breast Cancer, Stage II Breast Cancer, Stage IIIA Breast Cancer, Stage IIIB Breast Cancer, Stage IIIC Breast Cancer

In brief

This randomized phase I trial is studying the side effects of celecoxib in treating postmenopausal women with invasive breast cancer who are scheduled to undergo surgery at Memorial Sloan-Kettering Cancer Center. Celecoxib may stop the growth of tumor cells by blocking the enzymes necessary for tumor cell growth.

Key facts

Study ID

NCT00070057

Run by

National Cancer Institute (NCI)

People needed

75

Starts

2003-04-01

Expected to finish

2010-02-01

Last updated by the study team

2016-12-29

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Histologically confirmed invasive breast carcinoma
• Tumor at least 1 cm by radiologic estimate or physical exam
• No disease limited to ductal carcinoma in situ only
• Planning to undergo surgery at Memorial Sloan-Kettering Cancer Center
• Hormone receptor status:
• Not specified
• Female
• Postmenopausal as defined by at least 1 of the following:
• No menstrual period within the past 12 months
• Prior bilateral oophorectomy
• No known liver disease
• No renal insufficiency
• No congestive heart failure
• No coronary artery disease
• No history of documented peptic ulcer disease
• No gastritis
• No medical condition that would preclude definitive surgery
• No allergy to NSAIDs or sulfa-containing drugs
• No connective tissue diseases, including any of the following:
• Systemic lupus erythematosus
• Reynaud's disease
• Scleroderma
• More than 3 months since prior chemotherapy
• More than 2 weeks since prior hormone replacement therapy
• More than 2 weeks since prior tamoxifen

Where it is running

• Memorial Sloan-Kettering Cancer Center — New York, New York, United States

Full record on ClinicalTrials.gov

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