Independent Studies of Dextromethorphan and of Donepezil Hydrochloride for Rett Syndrome

Status unconfirmed · Phase 3

Conditions studied: Rett Syndrome

In brief

Rett syndrome (RTT) is a disorder in which the nervous system does not develop properly. RTT generally affects girls, but there are some boys who have been diagnosed with RTT. Symptoms of RTT include small brain size, poor language skills, repetitive hand movements, and seizures. This study will evaluate the effectiveness of two drugs in treating the symptoms of RTT.

Key facts

Study ID

NCT00069550

Run by

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

People needed

90

Starts

2004-09-01

Expected to finish

2008-06-01

Last updated by the study team

2005-06-24

Who can join

Age: 1 and older, up to 15. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of Rett syndrome
• Mutation in MeCP2 gene
• Typical EEG abnormalities (disorganized background, frontal central spikes, rhythmic theta)

You may not qualify if…

• Features of Rett syndrome with absence of MeCP2 mutation
• Non-specific EEG changes

Where it is running

• Kennedy Krieger Institute — Baltimore, Maryland, United States (enrolling)

Full record on ClinicalTrials.gov

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