Oxidative Stress and Vitamin E Requirements

Completed · Phase 2

Conditions studied: Smoking

In brief

The purpose of this study is to determine if oxidative stress derived from cigarette smoking increases vitamin E requirements. The study will also assess the role of vitamin C in modulating vitamin E requirements. Vitamin E requirements will be assessed by measuring vitamin E in plasma as well as by measuring the excreted vitamin E metabolite in the urine.

Key facts

Study ID

NCT00067899

Run by

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

People needed

99

Starts

2000-09-01

Expected to finish

2005-12-01

Last updated by the study team

2013-06-19

Who can join

Age: 18 and older, up to 35. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• non-smoking status or smokers (more than 1 pack per day)
• age: 18-35 y
• stable body weight, ranging between 80% and 130%,
• maintenance of normal exercise and activity patterns
• total cholesterol ≤ 7.758 mmol/L (300 mg/dl)
• triglyceride concentration ≤ 3.387 mmol/L (300 mg/dl)
• Subjects will be excluded if they fulfill any one of the following:
• antioxidant supplement users
• resting blood pressure above 160/105 mm Hg
• engaged in aerobic activity more than five hours per week
• vegetarian or other restrictive dietary requirements
• fasting blood glucose concentration of ≥ 7.77 mmol/L (140 mg/dl)
• history of diabetes or uremia
• other known metabolic disease or medication use known to affect lipid metabolism

Where it is running

• Linus Pauling Institute - Oregon State University — Corvallis, Oregon, United States

Full record on ClinicalTrials.gov

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