Bevacizumab Plus Fluorouracil and Leucovorin in Treating Patients With Locally Advanced or Metastatic Stage IV Colorectal Cancer That Has Progressed After Standard Chemotherapy

Completed · Phase 2

Conditions studied: Colorectal Cancer

In brief

RATIONALE: Bevacizumab may stop the growth of tumor cells by blocking the enzymes necessary for cancer cell growth. Drugs used in chemotherapy such as fluorouracil and leucovorin use different ways to stop tumor cells from dividing so they stop growing or die. Combining bevacizumab with fluorouracil and leucovorin may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combining bevacizumab with fluorouracil and leucovorin in treating patients who have locally advanced or metastatic stage IV colorectal cancer that has progressed after standard chemotherapy.

Key facts

Study ID

NCT00066846

Run by

National Cancer Institute (NCI)

Starts

2003-08-01

Expected to finish

2007-07-01

Last updated by the study team

2013-06-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Providence Alaska Medical Center — Anchorage, Alaska, United States
• Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States
• USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
• University of Colorado Cancer Center at University of Colorado Health Sciences Center — Aurora, Colorado, United States
• Yale Comprehensive Cancer Center — New Haven, Connecticut, United States
• Lombardi Cancer Center — Washington D.C., District of Columbia, United States
• CCOP - Atlanta Regional — Atlanta, Georgia, United States
• Robert H. Lurie Comprehensive Cancer Center, Northwestern University — Chicago, Illinois, United States
• Loyola University Medical Center — Maywood, Illinois, United States
• Holden Comprehensive Cancer Center — Iowa City, Iowa, United States
• Siouxland Hematology-Oncology — Sioux City, Iowa, United States
• CCOP - Wichita — Wichita, Kansas, United States
• Cancer Care of Maine — Bangor, Maine, United States
• Saint Joseph Mercy Health System — Ann Arbor, Michigan, United States
• St. Mary's/Duluth Clinic Cancer Center — Duluth, Minnesota, United States
• University of Mississippi Medical Center — Jackson, Mississippi, United States
• CCOP - Montana Cancer Consortium — Billings, Montana, United States
• Southern Nevada Cancer Research Foundation — Las Vegas, Nevada, United States
• Norris Cotton Cancer Center — Lebanon, New Hampshire, United States
• Roswell Park Cancer Institute — Buffalo, New York, United States
• New York Weill Cornell Cancer Center at Cornell University — New York, New York, United States
• Duke Comprehensive Cancer Center — Durham, North Carolina, United States
• Comprehensive Cancer Center at Wake Forest University — Winston-Salem, North Carolina, United States
• Meritcare Roger Maris Cancer Center — Fargo, North Dakota, United States
• Ireland Cancer Center — Cleveland, Ohio, United States

Full record on ClinicalTrials.gov

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