Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers

Completed · Phase 2

Conditions studied: Periodontitis, Periodontal Diseases

In brief

The purpose of this study is to determine in current and non-smokers the clinical and microbiological effects of 3 therapies: scaling and root planing (SRP) alone; SRP in combination with the orally administered antibiotic metronidazole; and SRP with the orally administered antibiotics metronidazole and amoxicillin along with the locally delivered antibiotic doxycycline at periodontal pockets \>= 4 mm.

Key facts

Study ID

NCT00066066

Run by

The Forsyth Institute

People needed

146

Starts

2003-07-01

Expected to finish

2009-07-01

Last updated by the study team

2013-04-22

Who can join

Age: 20 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• > 20 teeth
• > 5% sites (approx. 8 sites) with pocket depth > 4 mm and / or 5% sites with attachment level > 4 mm and mean AL < 4.5 mm and mean PD < 3.9 mm (not including tooth brush abrasions).

You may not qualify if…

• > 50% of sites with pocket depth or attachment level > 4 mm
• Pregnancy or nursing
• Periodontal or antibiotic therapy in the previous 6 months
• Any systemic condition which might influence the course of periodontal disease or treatment (e.g. diabetes, AIDS)
• Any systemic condition which requires antibiotic coverage for routine periodontal procedures (e.g. heart conditions, joint replacements etc.)
• Liver disease
• Any known allergy to amoxicillin, metronidazole or doxycycline
• Lactose intolerance

Where it is running

• Department of Periodontology — Cambridge, Massachusetts, United States

Full record on ClinicalTrials.gov

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