Antioxidant Functions of Lipoic Acid

Completed · Phase 2

Conditions studied: Hypercholesterolemia

In brief

The goal of this study is to determine whether a short treatment with lipoic acid, an antioxidant used in the treatment of diabetic neuropathy, improves blood vessel reactivity and decreases oxidant stress in persons with elevated blood cholesterol.

Key facts

Study ID

NCT00065624

Run by

National Center for Complementary and Integrative Health (NCCIH)

People needed

16

Starts

2003-11-01

Expected to finish

2007-07-01

Last updated by the study team

2007-10-02

Who can join

Age: 50 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Lipid criteria for inclusion are a plasma LDL between 160 and 190 mg/dl (total cholesterol usually 240-285 mg/dl)
• Less than 2 coronary risk factors, and already on a cholesterol-lowering diet.

You may not qualify if…

• Overt or clinical atherosclerosis
• Diabetes
• Currently taking cholesterol-lowering medication.
• Subjects with other lipid disorders
• Subjects taking supplemental lipoic acid, vitamin C, or vitamin E.

Where it is running

• Vanderbilt University Medical Center — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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