Comparison of Two Methods to Diagnose Coronary Artery Disease

Completed

Conditions studied: Cardiovascular Diseases, Coronary Disease, Heart Diseases

In brief

The purpose of this study is to compare two methods of diagnosing coronary artery disease (CAD), thallium single photon emission computed tomography (SPECT) and ultrafast computed tomography (CT).

Key facts

Study ID

NCT00063531

Run by

Johns Hopkins University

People needed

650

Starts

2003-06-01

Expected to finish

2007-01-01

Last updated by the study team

2018-04-18

Who can join

Age: 30 and older, up to 59. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Siblings of hospitalized index patients with documented CAD prior to 60 years of age
• Index patients who have demonstrated angiographic lesions greater than or equal to 50% in greater than or equal to 1 vessel, accompanied by angina or a documented CAD event
• Siblings with no known history of CAD
• Siblings with a positive screening test for occult CAD (abnormal ETT or thallium scan, or CAC score greater than 75th percentile) will be invited for coronary angiography

You may not qualify if…

• Index patients with CAD associated with some other primary disease (e.g., collagen vascular disease, transplantation, or chronic corticosteroid therapy)
• Siblings with a life-threatening comorbidity (e.g., AIDS, cancer)
• Siblings who have had an organ transplant
• Siblings receiving chronic glucocorticosteroids
• Siblings with known collagen vascular disease
• Siblings with a limitation that would preclude the capacity to exercise sufficiently for the test
• Siblings unable to give informed consent

Where it is running

• Johns Hopkins University School of Medicine — Baltimore, Maryland, United States

Full record on ClinicalTrials.gov

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