Oxaliplatin and Bevacizumab (Avastin™) With Either Fluorouracil and Leucovorin or Capecitabine in Treating Patients With Advanced Colorectal Cancer

Completed · Phase 3

Conditions studied: Colorectal Cancer

In brief

RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, fluorouracil, leucovorin, and capecitabine, work in different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug and giving them in different combinations may kill more tumor cells. Monoclonal antibodies, such as bevacizumab (Avastin™), can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or deliver cancer-killing substances to them. It is not yet known which regimen works better in treating advanced colorectal cancer. PURPOSE: This randomized phase III trial is to see if oxaliplatin and bevacizumab work better when combined with either fluorouracil and leucovorin or capecitabine in treating patients who have metastatic or recurrent colorectal cancer.

Key facts

Study ID

NCT00062426

Run by

Prologue Research International

Starts

2003-05-01

Expected to finish

2011-02-01

Last updated by the study team

2013-11-06

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Arizona Clinical Research Center — Tucson, Arizona, United States
• California Cancer Care, Inc. — Greenbrae, California, United States
• Valley Tumor Medical Group — Lancaster, California, United States
• Cancer and Blood Institute of the Desert — Rancho Mirage, California, United States
• Rocky Mountain Cancer Centers - Midtown — Denver, Colorado, United States
• Northwestern Connecticut Oncology-Hematology Associates — Torrington, Connecticut, United States
• Lombardi Cancer Center at Georgetown University Medical Center — Washington D.C., District of Columbia, United States
• Lynn Regional Cancer Center West — Boca Raton, Florida, United States
• Florida Cancer Specialists — Fort Myers, Florida, United States
• Florida Oncology Associates — Jacksonville, Florida, United States
• Hematology and Oncology Consultants, P.A. — Orlando, Florida, United States
• Hematology Oncology Associates of theTreasure Coast - Port St. Lucie — Port Saint Lucie, Florida, United States
• Palm Beach Cancer Institute — West Palm Beach, Florida, United States
• Peachtree Hematology and Oncology Consultants, P.C. — Atlanta, Georgia, United States
• North Idaho Cancer Center — Coeur d'Alene, Idaho, United States
• Robert H. Lurie Comprehensive Cancer Center at Northwestern University — Chicago, Illinois, United States
• Lutheran General Cancer Care Center — Park Ridge, Illinois, United States
• West Suburban Center for Cancer Care — River Forest, Illinois, United States
• Saint Anthony Medical Center — Rockford, Illinois, United States
• CCOP - Northern Indiana CR Consortium — South Bend, Indiana, United States
• Cedar Rapids Oncology Associates — Cedar Rapids, Iowa, United States
• CCOP - Wichita — Wichita, Kansas, United States
• Greater Baltimore Medical Center and Cancer Center — Baltimore, Maryland, United States
• Jackson Oncology Associates, PLLC — Jackson, Mississippi, United States
• University of Alabama at Birmingham Comprehensive Cancer Center — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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