Vinblastine, Celecoxib, and Combination Chemotherapy in Treating Patients With Newly-Diagnosed Metastatic Ewing's Sarcoma Family of Tumors

Completed · Phase 2

Conditions studied: Sarcoma

In brief

RATIONALE: Drugs used in chemotherapy, such as vinblastine, work in different ways to stop tumor cells from dividing so they stop growing or die. Celecoxib may stop the growth of Ewing's sarcoma by stopping blood flow to the tumor. Combining more than one chemotherapy drug with celecoxib may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combining low-dose vinblastine and celecoxib with standard regimens of combination chemotherapy in treating patients who have newly-diagnosed metastatic Ewing's sarcoma family of tumors.

Key facts

Study ID

NCT00061893

Run by

Children's Oncology Group

People needed

38

Starts

2004-04-01

Expected to finish

2013-12-01

Last updated by the study team

2019-02-15

Who can join

Age: any, up to 50. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Phoenix Children's Hospital — Phoenix, Arizona, United States
• Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
• Southern California Permanente Medical Group — Downey, California, United States
• Loma Linda University Cancer Institute at Loma Linda University Medical Center — Loma Linda, California, United States
• Jonathan Jaques Children's Cancer Center at Miller Children's Hospital — Long Beach, California, United States
• Childrens Hospital Los Angeles — Los Angeles, California, United States
• Children's Hospital Central California — Madera, California, United States
• University of California Davis Cancer Center — Sacramento, California, United States
• Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center — Farmington, Connecticut, United States
• Alfred I. duPont Hospital for Children — Wilmington, Delaware, United States
• Lee Cancer Care of Lee Memorial Health System — Fort Myers, Florida, United States
• Nemours Children's Clinic — Jacksonville, Florida, United States
• University of Miami Sylvester Comprehensive Cancer Center — Miami, Florida, United States
• Florida Hospital Cancer Institute at Florida Hospital Orlando — Orlando, Florida, United States
• Nemours Children's Clinic - Orlando — Orlando, Florida, United States
• Sacred Heart Cancer Center at Sacred Heart Hospital — Pensacola, Florida, United States
• All Children's Hospital — St. Petersburg, Florida, United States
• St. Joseph's Cancer Institute at St. Joseph's Hospital — Tampa, Florida, United States
• Kaplan Cancer Center at St. Mary's Medical Center — West Palm Beach, Florida, United States
• Winship Cancer Institute of Emory University — Atlanta, Georgia, United States
• MBCCOP - Medical College of Georgia Cancer Center — Augusta, Georgia, United States
• Curtis & Elizabeth Anderson Cancer Institute at Memorial Health University Medical Center — Savannah, Georgia, United States
• Southern Illinois University School of Medicine — Springfield, Illinois, United States
• Indiana University Cancer Center — Indianapolis, Indiana, United States
• University of Alabama at Birmingham Comprehensive Cancer Center — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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