Magnetic Resonance Imaging of the Brain in Emotional Processing
Completed
Conditions studied: Healthy
In brief
This study will use magnetic resonance imaging (MRI) to identify brain regions involved in performing certain tasks, especially those involving emotions. MRI is a diagnostic tool that uses a strong magnetic field and radio waves to produce images of structural and chemical changes in the brain. The study will also examine which MRI techniques are best to use when scanning brain areas involved in different emotions. Healthy normal volunteers between 18 and 40 years of age who are right-handed and are native English speakers may be eligible for this study. Individuals with a history of neurological disease, post-traumatic stress disorder or other psychiatric disorder, or who have a history of physical or sexual abuse may not participate. Candidates will be screened with a written questionnaire and a medical history, including psychiatric and neurological information. Participants will perform tasks involving emotions while undergoing MRI scanning. For this procedure, the subject lies on a table in a narrow metal cylinder (the scanner) containing a magnetic field. Scanning time varies from 20 minutes to 3 hours, with most scans lasting between 45 and 90 minutes. The subject is asked to lie still for up to 10 minutes at a time. During the scan, the subject performs simple tasks involving the viewing of pictures on a screen. Other tasks involve viewing pictures and responding to them by pressing buttons. Some pictures are violent or pornographic, while others are pleasant to view. Of a total of 162 pictures, 30 percent are categorized as graphic and possibly disturbing.
Key facts
- Study ID
- NCT00061204
- Run by
- National Institute of Neurological Disorders and Stroke (NINDS)
- People needed
- 38
- Starts
- 2003-05-01
- Expected to finish
- 2006-04-01
- Last updated by the study team
- 2008-03-04
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- The study population will consist of young healthy volunteers.
- Age range: 18 to 40
- Right-handedness (some left-handed subjects may be recruited for preliminary behavioral studies)
You may not qualify if…
- Individuals with a neurological or psychiatric history or medical condition that would compromise our interpretation of the fMRI results will be excluded.
- Individuals with a current or past history of post-traumatic stress disorder or other psychiatric disorder or individuals with a history of physical or sexual abuse will be excluded as they may be disturbed by viewing graphic pictures.
- Subjects with contraindications to exposure to high magnetic field.
Where it is running
- National Institute of Neurological Disorders and Stroke (NINDS) — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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