ABX-EGF (a Monoclonal Antibody) Given to Patients With Prostate Cancer With or Without Tumor in Other Parts of the Body

Completed · Phase 2

Conditions studied: Prostate Cancer

In brief

A clinical trial examining the safety and effectiveness of ABX-EGF when given to patients with prostate cancer with or without tumor in other parts of the body. Patients will be treated for a maximum of 48 doses (6 treatment courses; 8 doses per course) or until evidence of progressive disease.

Key facts

Study ID

NCT00061126

Run by

Abgenix

People needed

50

Starts

2003-04-01

Last updated by the study team

2005-06-24

Who can join

Age: 18 and older. Sex: male. Healthy volunteers: not accepted.

You may qualify if…

• Male 18 years of age or older
• Has tumor tissue available for diagnostics
• Failed front line luteinizing hormone-releasing hormone analogue (LHRH) such as leuprolide or goserelin, or failed orchiectomy, as evidenced by disease progression. Patients must continue on a LHRH analogue (unless the patient had an orchiectomy) throughout the course of the study
• ECOG score of 0 or 1

You may not qualify if…

• Any prior chemotherapy for prostate cancer besides hormonal therapy (including no prior EGFr targeting agent)
• Prior history of cancer other than prostate carcinoma within the past 5 years that has required treatment or been active (prior basal cell carcinoma is allowed)
• Known to be HIV positive
• Myocardial infarction within one year prior to entering the study

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• UCLA School of Medicine — Los Angeles, California, United States
• Stanford Medical Center — Stanford, California, United States
• Advanced Research Institute — New Port Richey, Florida, United States
• Fox Chase Cancer Center — Philadelphia, Pennsylvania, United States
• University of Pittsburgh Cancer Institute, Hillman Cancer Center — Pittsburgh, Pennsylvania, United States
• Urology San Antonio Research — San Antonio, Texas, United States
• University of Washington — Seattle, Washington, United States
• Madigan Army Medical Center — Tacoma, Washington, United States

Full record on ClinicalTrials.gov

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