Magnetic Resonance Imaging of the Brain in Social and Emotional Reasoning
Completed
Conditions studied: Healthy
In brief
This study will use magnetic resonance imaging (MRI) to identify brain regions involved in social and emotional reasoning. It will identify differences in brain activity during task performance between people who have a nervous system illness and those who do not. MRI is a diagnostic tool that uses a strong magnetic field and radio waves to produce images of structural and chemical changes in the brain. Healthy normal volunteers between 21 and 55 years of age who are right-handed and are native English speakers may be eligible for this study. Candidates will be screened with a medical history, including psychiatric and neurological information. Participants will be asked to perform social and emotional reasoning tasks, such as sorting and judging rules and rule violations, while undergoing MRI scanning. Some tasks may simply involve viewing items on a screen. Others may involve solving complex problems and responding by pressing buttons. During the scan, the subject lies on a table in a narrow cylinder (the scanner) containing a magnetic field. The scan will last about 2 hours, with subjects asked to lie still for up to 10 minutes at a time.
Key facts
- Study ID
- NCT00060853
- Run by
- National Institute of Neurological Disorders and Stroke (NINDS)
- People needed
- 330
- Starts
- 2003-05-01
- Expected to finish
- 2005-05-01
- Last updated by the study team
- 2008-03-04
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- In all the studies, subjects will consist of healthy, native English-speaking, right-handed volunteers, as measured by the Edinburgh Handedness Inventory. Subjects will range in age from 21 to 55 years old and they will be included regardless of race.
- In studies 4 and 5, equal numbers of males and females will be recruited owing to previous findings of significant sex differences on such tests. In all other studies subjects will be recruited indiscriminately on the basis of sex.
You may not qualify if…
- Non-native English speakers and non-right handers will be excluded as mentioned above, as will non-neurologically normal volunteers. Subjects younger than 21 and older than 55 will be excluded. A pregnancy test will be employed with all women of childbearing age. The results must be negative in order to proceed with the MRI.
- Subjects with any of the following: aneurysm clip; implanted neural stimulator; implanted cardiac pacemaker or auto-defibrillator; cochlear implant; ocular foreign body, e.g. metal shavings; insulin pump; or irremovable body piercing will be excluded from the study due to the possible dangerous effects of the magnet upon metal objects in the body.
Where it is running
- National Institute of Neurological Disorders and Stroke (NINDS) — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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