Comparative Trial for Pixantrone in Combination With Rituximab in Indolent Non-Hodgkin's Lymphoma

Stopped early · Phase 3

Conditions studied: Lymphoma, Follicular, Lymphoma, Mixed-Cell, Follicular, Lymphoma, Small Cleaved-Cell, Follicular, Lymphoma, Low-Grade

In brief

The purpose of this study is to determine whether combining pixantrone (BBR 2778, INN name pending) with the monoclonal antibody rituximab, leads to an increase in the period of patients' remission, compared to rituximab alone.

Key facts

Study ID

NCT00060671

Run by

CTI BioPharma

People needed

800

Starts

2005-01-01

Expected to finish

2006-01-01

Last updated by the study team

2015-01-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with relapsed or refractory indolent non-Hodgkin's lymphoma (NHL), including follicular lymphoma grade I and II
• Presenting with an episode of progressive disease, following 1-5 prior treatments (with either radiation, chemotherapy or rituximab).

You may not qualify if…

• Patients that failed to respond to previous rituximab treatment, or relapsed within 6 months of the first rituximab infusion
• Patients known to have an allergic reaction to rituximab or murine derived proteins.

Where it is running

• Arizona Clinical Research Center — Tucson, Arizona, United States
• Sutter Health Western Division Cancer Research Group — Greenbrae, California, United States
• Kenmar Research Institute — Los Angeles, California, United States
• Rocky Moutain Cancer Center — Denver, Colorado, United States
• Pasco, Hernando Oncology Associates, P.A. — New Port Richey, Florida, United States
• Ocala Oncology Center — Ocala, Florida, United States
• Orange Park Cancer Center — Orange Park, Florida, United States
• University of Chicago Medical Center Hematology / Oncology — Chicago, Illinois, United States
• Illinois Masonic Cancer Center — Chicago, Illinois, United States
• Edward Cancer Center — Naperville, Illinois, United States
• Hope Center — Terre Haute, Indiana, United States
• Commonwealth Hematology/Oncology — Danville, Kentucky, United States
• New England Hematology / Oncology Associates — Wellesley, Massachusetts, United States
• St. Joseph Oncology — Saint Joseph, Missouri, United States
• Christian Hospital — St Louis, Missouri, United States
• St. Johns Mercy Medical Center — St Louis, Missouri, United States
• Hematology - Oncology Centers of N. Rockies — Billings, Montana, United States
• Great Falls Clinic — Great Falls, Montana, United States
• East Orange VA Medical Center — East Orange, New Jersey, United States
• Hematology Oncology Associates of NJ — Paramus, New Jersey, United States
• Summit Medical Group/Overlook Onc Center — Summit, New Jersey, United States
• New Mexico Oncology / Hematology — Albuquerque, New Mexico, United States
• HemOnCare, P.C. — Brooklyn, New York, United States
• Glens Falls Cancer Center — Glens Falls, New York, United States
• North Shore - Long Island Jewish Health System — New Hyde Park, New York, United States

Full record on ClinicalTrials.gov

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