Research Evaluating the Value of Augmenting Medication With Psychotherapy

Completed · Phase 4

Conditions studied: Depression, Depressive Disorder

In brief

This 24-week study, with a 12-month follow up period, will compare the effectiveness of antidepressant medication alone to the combination of psychotherapy and antidepressant medication in patients with chronic depression.

Key facts

Study ID: NCT00057551
Run by: Weill Medical College of Cornell University
People needed: 491
Starts: 2003-04-01
Expected to finish: 2007-03-01
Last updated by the study team: 2017-12-06

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Major depressive episode
Depressive symptoms > 2 years without remission
Hamilton Depression Scale (HAM-D) score > 20
Fluent in English

You may not qualify if…

Psychotic disorders, bipolar disorder, post traumatic stress disorder, obsessive compulsive disorder, or eating disorder
Serious, unstable, or terminal medical condition
Axis II diagnosis of antisocial, schizotypal, or severe borderline personality disorder
Previous treatment with CBASP
Previous ineffective treatment with 4 of the medication treatments used in the study
Substance abuse
Pregnancy
Not willing to end other psychiatric treatment

Where it is running

University of Arizona — Tucson, Arizona, United States
Stanford University — Palo Alto, California, United States
Emory University — Atlanta, Georgia, United States
Weill-Cornell Medical College Payne Whitney Clinic — New York, New York, United States
SUNY- Stony Brook — New York, New York, United States
University of Pittsburgh — Pittsburgh, Pennsylvania, United States
Brown University — Providence, Rhode Island, United States
University of Texas Southwestern Medical Center — Dallas, Texas, United States

Full record on ClinicalTrials.gov

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