Safety and Efficacy Study of YM087 (Conivaptan) in Patients With Acute Decompensated Heart Failure

Completed · Phase 2 · Has a placebo group

Conditions studied: Chronic Heart Failure

In brief

This is a randomized, double-blind, placebo-controlled, dose ranging pilot study to examine the effects of conivaptan in patients with acute decompensated heart failure.

Key facts

Study ID

NCT00057356

Run by

Cumberland Pharmaceuticals

People needed

170

Starts

2002-11-01

Expected to finish

2004-03-01

Last updated by the study team

2014-05-02

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients may be male or female age 18 years or older.
• Women must be post-menopausal or surgically sterile.
• Patients must have chronic heart failure of at least 2 months duration and be hospitalized for the treatment of worsening heart failure. The primary manifestation of worsening heart failure must be worsening dyspnea.

Where it is running

• The Heart Center, P.C. — Huntsville, Alabama, United States
• LA County/USC Medical Center — Los Angeles, California, United States
• San Joaquin Cardiology — Manteca, California, United States
• Apex Research Institute — Santa Ana, California, United States
• The Greater Fort Lauderdale Heart Group Research — Fort Lauderdale, Florida, United States
• Jacksonville Center for Clinical Research — Jacksonville, Florida, United States
• U. Miami, Jackson Mem'l Medical Center — Miami, Florida, United States
• Discovery Medical Research Group — Ocala, Florida, United States
• Rush-Presbyterian St. Luke's Medical Center — Chicago, Illinois, United States
• Louisiana State University Medical Center School of Medicine — New Orleans, Louisiana, United States
• New Orleans Center for Clinical Research — New Orleans, Louisiana, United States
• Cardiac Centers of Louisiana, LLC — Shreveport, Louisiana, United States
• University of Maryland Hospital — Baltimore, Maryland, United States
• Hennepin County Medical Center — Minneapolis, Minnesota, United States
• Washington University — St Louis, Missouri, United States
• Dartmouth-Hitchcock Medical Center — Lebanon, New Hampshire, United States
• New York Presbyterian Hosp, Milstein Hosp. — New York, New York, United States
• University of Cincinnati, College of Medicine, Div. of Cardiology — Cincinnati, Ohio, United States
• The Cleveland Clinic Foundation — Cleveland, Ohio, United States
• Ohio State University Medical Center, Heart and Lung Research Institute — Columbus, Ohio, United States
• Hershey Medical Center — Hershey, Pennsylvania, United States
• Medical University of South Carolina — Charleston, South Carolina, United States
• Baptist Clinical Research — Memphis, Tennessee, United States
• Cardiovascular Research Institute of Dallas — Dallas, Texas, United States
• Baylor College of Medicine — Houston, Texas, United States

Full record on ClinicalTrials.gov

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