Clinical and Genetic Studies of Families With Congenital or Hereditary Cataracts
Completed
Conditions studied: Cataract
In brief
This study will explore the clinical and hereditary (genetic) features of inherited cataracts. A cataract is a clouding of the eye lens, which focuses light on the back of the eye. When the lens becomes cloudy and does not let light through, vision is impaired. Cataracts may be associated with vision problems alone, or with other problems, such as changes in facial appearance or skin problems. A better understanding of these genetic conditions may help in the development of better diagnostic tests. Patients with inherited cataracts and their family members may be eligible for this study. Participants will be drawn from patients enrolled in other studies of inherited cataracts at the NEI and collaborating clinics. Participants will undergo the following tests and procedures: * Medical and surgical history; * Verification of diagnosis; * Construction of a family tree regarding familial vision problems; * Complete eye examination, including dilation of the pupils and photography of the lens, tests of color vision and field of vision, and of the ability to see in the dark; * Blood sample collection (20 ml, or 4 teaspoons) for genetic studies of hereditary cataracts.
Key facts
- Study ID
- NCT00056771
- Run by
- National Eye Institute (NEI)
- People needed
- 3432
- Starts
- 2003-03-18
- Expected to finish
- 2016-05-25
- Last updated by the study team
- 2018-04-05
Who can join
Age: 4 and older. Sex: any. Healthy volunteers: not accepted.
You may not qualify if…
- Diseases, infections, or trauma that mimic inherited cataracts.
- Children requiring sedation for study procedures.
Where it is running
- National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
- Zhongshan Ophthalmic Center — Guangzhou, China
- Aravind Eye Hospital — Maduri, India
- University of Parma — Parma, Italy
- Centre for Excellence in Molecular Biology — Lahore, Pakistan
Full record on ClinicalTrials.gov
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