Chemotherapy and Radiation Therapy With or Without Surgery in Treating Patients With Stage I Cancer of the Cervix

Stopped early · Phase 3

Conditions studied: Cervical Cancer

In brief

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known which regimen of radiation therapy combined with chemotherapy, with or without surgery, is more effective in treating early cancer of the cervix. PURPOSE: Randomized phase III trial to compare the effectiveness of surgery followed by different regimens of radiation therapy and chemotherapy with that of chemotherapy and radiation therapy alone in treating patients who have stage I cancer of the cervix.

Key facts

Study ID

NCT00054067

Run by

Gynecologic Oncology Group

Starts

2003-02-01

Last updated by the study team

2013-04-11

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

Where it is running

• University of Alabama at Birmingham Comprehensive Cancer Center — Birmingham, Alabama, United States
• CCOP - Western Regional, Arizona — Phoenix, Arizona, United States
• Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States
• Women's Cancer Center at Community Hospital of Los Gatos — Los Gatos, California, United States
• Chao Family Comprehensive Cancer Center at University of California Irvine Cancer Center — Orange, California, United States
• Yale Comprehensive Cancer Center — New Haven, Connecticut, United States
• CCOP - Christiana Care Health Services — Newark, Delaware, United States
• Walter Reed Army Medical Center — Washington D.C., District of Columbia, United States
• Rush-Presbyterian-St. Luke's Medical Center — Chicago, Illinois, United States
• MBCCOP - University of Illinois at Chicago — Chicago, Illinois, United States
• University of Chicago Cancer Research Center — Chicago, Illinois, United States
• CCOP - Central Illinois — Decatur, Illinois, United States
• CCOP - Evanston — Evanston, Illinois, United States
• CCOP - Carle Cancer Center — Urbana, Illinois, United States
• Indiana University Cancer Center — Indianapolis, Indiana, United States
• Saint Joseph Regional Medical Center — South Bend, Indiana, United States
• Holden Comprehensive Cancer Center at University of Iowa — Iowa City, Iowa, United States
• Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support — Bethesda, Maryland, United States
• CCOP - Michigan Cancer Research Consortium — Ann Arbor, Michigan, United States
• CCOP - Grand Rapids — Grand Rapids, Michigan, United States
• CCOP - Kalamazoo — Kalamazoo, Michigan, United States
• CCOP - Metro-Minnesota — Saint Louis Park, Minnesota, United States
• University of Mississippi Medical Center — Jackson, Mississippi, United States
• Ellis Fischel Cancer Center at University of Missouri - Columbia — Columbia, Missouri, United States
• CCOP - Kansas City — Kansas City, Missouri, United States

Full record on ClinicalTrials.gov

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