Pirfenidone in Treating Young Patients With Neurofibromatosis Type 1 and Plexiform Neurofibromas

Completed · Phase 1

Conditions studied: Neurofibromatosis Type 1, Precancerous Condition

In brief

RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. Pirfenidone may slow the growth or prevent further development of plexiform neurofibromas. PURPOSE: Phase I trial to study the effectiveness of pirfenidone in treating young patients who have neurofibromatosis type 1 and plexiform neurofibroma.

Key facts

Study ID

NCT00053937

Run by

National Cancer Institute (NCI)

Starts

2002-12-01

Last updated by the study team

2015-04-30

Who can join

Age: 3 and older, up to 21. Sex: any. Healthy volunteers: not accepted.

Where it is running

• University of Alabama at Birmingham Comprehensive Cancer Center — Birmingham, Alabama, United States
• Children's National Medical Center — Washington D.C., District of Columbia, United States
• Children's Memorial Hospital - Chicago — Chicago, Illinois, United States
• Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins — Baltimore, Maryland, United States
• Warren Grant Magnuson Clinical Center - NCI Clinical Studies Support — Bethesda, Maryland, United States
• Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute — Boston, Massachusetts, United States
• Mayo Clinic Cancer Center — Rochester, Minnesota, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• Beth Israel Medical Center - Singer Division — New York, New York, United States
• University Hospital at State University of New York - Upstate Medical University — Syracuse, New York, United States
• Cleveland Clinic Taussig Cancer Center — Cleveland, Ohio, United States
• Cancer Institute at Oregon Health and Science University — Portland, Oregon, United States
• Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States
• Children's Hospital of Pittsburgh — Pittsburgh, Pennsylvania, United States
• Texas Children's Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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