Anastrozole or Tamoxifen in Treating Postmenopausal Women With Ductal Carcinoma in Situ Who Are Undergoing Lumpectomy and Radiation Therapy

Completed · Phase 3 · Has a placebo group

Conditions studied: Breast Cancer

In brief

RATIONALE: Estrogen can stimulate the growth of breast cancer cells. Tamoxifen may fight breast cancer by blocking the use of estrogen. Anastrozole may fight breast cancer by decreasing estrogen production. It is not yet known whether anastrozole is more effective than tamoxifen in preventing the recurrence of breast cancer. PURPOSE: This randomized phase III trial is studying anastrozole to see how well it works compared to tamoxifen in preventing the recurrence of breast cancer in postmenopausal women with ductal carcinoma in situ who are undergoing lumpectomy and radiation therapy.

Key facts

Study ID

NCT00053898

Run by

NSABP Foundation Inc

People needed

3104

Starts

2003-01-01

Expected to finish

2016-05-01

Last updated by the study team

2018-09-20

Who can join

Age: any. Sex: female. Healthy volunteers: not accepted.

Where it is running

• Comprehensive Cancer Center at University of Alabama at Birmingham — Birmingham, Alabama, United States
• Huntsville Hospital — Huntsville, Alabama, United States
• Mobile Infirmary Medical Center — Mobile, Alabama, United States
• East Alabama Medical Center — Opelika, Alabama, United States
• Cancer Center at Providence Alaska Medical Center — Anchorage, Alaska, United States
• Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital — Fairbanks, Alaska, United States
• Banner Thunderbird Medical Center — Glendale, Arizona, United States
• Banner Good Samaritan Medical Center — Phoenix, Arizona, United States
• CCOP - Western Regional, Arizona — Phoenix, Arizona, United States
• Mayo Clinic Scottsdale — Scottsdale, Arizona, United States
• Arizona Cancer Center at University of Arizona Health Sciences Center — Tucson, Arizona, United States
• Saint Joseph's Mercy Cancer Center — Hot Springs, Arkansas, United States
• Alta Bates Comprehensive Cancer Center — Berkeley, California, United States
• Providence Saint Joseph Medical Center - Burbank — Burbank, California, United States
• Peninsula Medical Center — Burlingame, California, United States
• Mount Diablo Regional Cancer Center — Concord, California, United States
• City of Hope Comprehensive Cancer Center — Duarte, California, United States
• North Bay Cancer Center — Fairfield, California, United States
• Kaiser Permanente - Fremont — Fremont, California, United States
• Washington Township Hospital — Fremont, California, United States
• California Cancer Center - Woodward Park Office — Fresno, California, United States
• Virginia K. Crosson Cancer Center at St. Jude Medical Center — Fullerton, California, United States
• Glendale Memorial Hospital Comprehensive Cancer Center — Glendale, California, United States
• Marin Cancer Institute at Marin General Hospital — Greenbrae, California, United States
• Northeast Alabama Regional Medical Center — Anniston, Alabama, United States

Full record on ClinicalTrials.gov

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