Donor Stem Cell Transplant in Treating Patients With Relapsed Hematologic Cancer
Completed · Phase 2
Conditions studied: Leukemia, Lymphoma, Multiple Myeloma, Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myeloproliferative Neoplasms
In brief
RATIONALE: Giving low doses of chemotherapy, such as fludarabine and busulfan, before a donor bone marrow or peripheral blood stem cell transplant helps stop the growth of cancer cells. It also stops the patient's immune system from rejecting the donor's stem cells. The donated stem cells may replace the patient's immune system and help destroy any remaining cancer cells (graft-versus-tumor effect). Giving an infusion of the donor's T cells (donor lymphocyte infusion) after the transplant may help increase this effect. Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving immunosuppressive therapy after the transplant may stop this from happening. PURPOSE: This phase II trial is studying how well donor bone marrow or peripheral stem cell transplant works in treating patients with relapsed hematologic cancer after treatment with chemotherapy and autologous stem cell transplant.
Key facts
- Study ID
- NCT00053196
- Run by
- Alliance for Clinical Trials in Oncology
- People needed
- 82
- Starts
- 2002-12-01
- Expected to finish
- 2010-08-01
- Last updated by the study team
- 2016-07-01
Who can join
Age: any, up to 69. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Rebecca and John Moores UCSD Cancer Center — La Jolla, California, United States
- Beebe Medical Center — Lewes, Delaware, United States
- CCOP - Christiana Care Health Services — Newark, Delaware, United States
- St. Francis Hospital — Wilmington, Delaware, United States
- Union Hospital Cancer Center at Union Hospital — Elkton MD, Maryland, United States
- Siteman Cancer Center at Barnes-Jewish Hospital — St Louis, Missouri, United States
- Cancer Institute of New Jersey at the Cooper University Hospital - Voorhees — Voorhees Township, New Jersey, United States
- Roswell Park Cancer Institute — Buffalo, New York, United States
- Wake Forest University Comprehensive Cancer Center — Winston-Salem, North Carolina, United States
- Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University — Columbus, Ohio, United States
- Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital — Pittsburgh, Pennsylvania, United States
- Massey Cancer Center at Virginia Commonwealth University — Richmond, Virginia, United States
Full record on ClinicalTrials.gov
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