Amifostine and Melphalan in Treating Patients With Primary Systemic Amyloidosis Who Are Undergoing Peripheral Stem Cell Transplantation
Stopped early · Phase 1
Conditions studied: Drug/Agent Toxicity by Tissue/Organ, Multiple Myeloma and Plasma Cell Neoplasm
In brief
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of plasma cells, either by killing the cells or by stopping them from dividing. Having a peripheral stem cell transplant to replace the blood-forming cells destroyed by chemotherapy, allows higher dose of chemotherapy to be given so that more plasma cells are killed. Giving a chemoprotective drug such as amifostine may protect kidney cells from the side effects of chemotherapy. PURPOSE: This phase I trial is studying the side effects and best dose of melphalan given together with amifostine in treating patients who are undergoing peripheral stem cell transplant for primary systemic amyloidosis.
Key facts
- Study ID
- NCT00052884
- Run by
- Eastern Cooperative Oncology Group
- People needed
- 8
- Starts
- 2004-01-22
- Expected to finish
- 2011-03-01
- Last updated by the study team
- 2023-06-18
Who can join
Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Mayo Clinic Scottsdale — Scottsdale, Arizona, United States
- Indiana University Melvin and Bren Simon Cancer Center — Indianapolis, Indiana, United States
- Fairview Ridges Hospital — Burnsville, Minnesota, United States
- Mercy and Unity Cancer Center at Mercy Hospital — Coon Rapids, Minnesota, United States
- Fairview Southdale Hospital — Edina, Minnesota, United States
- Mercy and Unity Cancer Center at Unity Hospital — Fridley, Minnesota, United States
- Minnesota Oncology Hematology, PA - Maplewood — Maplewood, Minnesota, United States
- Virginia Piper Cancer Institute at Abbott - Northwestern Hospital — Minneapolis, Minnesota, United States
- Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center — Robbinsdale, Minnesota, United States
- Mayo Clinic Cancer Center — Rochester, Minnesota, United States
- CCOP - Metro-Minnesota — Saint Louis Park, Minnesota, United States
- Park Nicollet Cancer Center — Saint Louis Park, Minnesota, United States
- United Hospital — Saint Paul, Minnesota, United States
- Ridgeview Medical Center — Waconia, Minnesota, United States
- Minnesota Oncology Hematology, PA - Woodbury — Woodbury, Minnesota, United States
- Case Comprehensive Cancer Center — Cleveland, Ohio, United States
Full record on ClinicalTrials.gov
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