Blood Vessel Function in HIV-Infected Patients Taking Anti-HIV Drugs

Completed

Conditions studied: HIV Infections

In brief

This is a substudy of ACTG A5142. The purpose of this substudy is to evaluate blood vessel function in HIV-infected patients taking anti-HIV drugs.

Key facts

Study ID

NCT00050908

Run by

National Institute of Allergy and Infectious Diseases (NIAID)

People needed

75

Expected to finish

2007-05-01

Last updated by the study team

2013-07-29

Who can join

Age: 13 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Participation in ACTG A5142 .
• Able and willing to give written informed consent and to report current smoking status.
• Men who have been on stable testosterone replacement for at least 3 months prior to entry and plan to continue to receive a stable dose during the substudy may enroll. Men who have discontinued testosterone therapy must be off for at least 3 months to be eligible.
• Women receiving oral contraceptives, hormone replacement, or progestational derivatives must have been on stable regimens for at least 3 months prior to enrollment and must plan to remain on the same dose for the duration of the study. Women who have discontinued such therapy must be off for at least 3 months to be eligible.

You may not qualify if…

• Coronary heart disease, peripheral vascular disease, or cerebrovascular disease.
• Diabetes mellitus, with the exception of a previous history of gestational or steroid-induced diabetes mellitus within 12 weeks prior to substudy entry.
• Insulin-sensitizing agents such as metformin, pioglitazone, and rosiglitazone.
• Lipid-lowering drugs within 6 weeks prior to substudy entry.
• Systemic glucocorticoids, long-acting inhaled steroids, and certain anabolic steroids within 30 days prior to substudy entry.
• Uncontrolled hypertension.
• Heavy use of vitamin supplements.

Where it is running

• UCLA School of Med — Los Angeles, California, United States
• Univ of California, San Diego Antiviral Research Ctr — San Diego, California, United States
• Univ of Hawaii — Honolulu, Hawaii, United States
• Northwestern Univ — Chicago, Illinois, United States
• Indiana Univ Hosp — Indianapolis, Indiana, United States
• Methodist Hosp of Indiana — Indianapolis, Indiana, United States
• Wishard Hosp — Indianapolis, Indiana, United States
• Chelsea Clinic — New York, New York, United States
• Univ of Cincinnati — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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