Effects of Leptin Treatment on Weight Loss
Completed · Phase 2 · Has a placebo group
Conditions studied: Obesity
In brief
This is a double blind placebo controlled clinical study designed to determine the effects of leptin on the changes that occur in the body during weight loss achieved by a very low calorie diet.
Key facts
- Study ID
- NCT00050791
- Run by
- Rockefeller University
- People needed
- 40
- Starts
- 2001-03-01
- Expected to finish
- 2009-06-01
- Last updated by the study team
- 2010-10-19
Who can join
Age: 20 and older, up to 45. Sex: female. Healthy volunteers: accepted.
You may qualify if…
- (1) adult females, age 25-45 with BMI 29-45, and no other acute or chronic illnesses. Pregnant women will not be permitted to participate in the study.
You may not qualify if…
- Chronic illnesses other the than mild forms illnesses related to obesity (hypertension, hyperlipidemia etc) that do not require medical treatment
- Diabetes Mellitus
- Chronic drug treatment for any medical conditions
- Inability to give informed consent
- Inability to give contact information (for outpatient follow up) including permanent residence, provide evidence of a stable living environment for the study period.
- Active weight reduction of more than 7 pounds in the last 3 months
- Weight at screening more than 6% lower than the maximal life time weight.
- History of bleeding or blood clotting disorders.
- Changes in smoking habits for the last 3 months.
- Pregnancy or breast feeding in women.
- Allergic reaction to local anesthetics
- History of anaphylaxis or anaphylactoid-like reactions
- Tendency to form scars (keloids) easily
- Subjects with known hypersensitivity to E Coli-derived proteins or any other component of the A-100 preparation.
- Irregular menses
- HIV and hepatitis B or C positive subjects.
Where it is running
- Rockefeller University Hospital — New York, New York, United States
Full record on ClinicalTrials.gov
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