To Study the Effects of CD25 and Low Dose Cyclosporin in the Treatment of Active Psoriasis Vulgaris
Completed · Phase 1/Phase 2
Conditions studied: Psoriasis
In brief
This study compares the efficacy and analyzes the cellular effects of anti-TAC (Daclizumab) and Cyclosporine in the treatment of psoriasis vulgaris. This is a three-armed study-Daclizumab alone, Cyclosporine alone, and the combination of both Daclizumab and Cyclosporine.
Key facts
- Study ID
- NCT00050648
- Run by
- Rockefeller University
- People needed
- 20
- Starts
- 1997-10-01
- Expected to finish
- 2008-04-01
- Last updated by the study team
- 2009-03-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Male or female patients with chronic psoriasis vulgaris (disease stable or worsening for > 6 months). Patients age 16 - 21 will be considered on a case by case basis. Patients below 18 will need parental consent.
- Extensive skin involvement.
- Scale, thickness, and erythema in individual psoriasis lesions of at least intensity.
- Psoriasis treated with emollients only for 2 weeks prior to treatment
- Patients with active psoriatic arthritis, if accompanied by psoriasis vulgaris involving more than 5% of the body surface.
- History of psoriasis that cannot be treated with topical agents or with previous systemic/ photo(chemo)therapy agents.
You may not qualify if…
- . Positive serology for HIV, Hepatitis B, or Hepatitis C.
- . Positive β-HCG titer. For women of childbearing potential, unwillingness or inability to use a contraceptive device during this study if negative for β-HCG.
- Guttate psoriasis, pustular psoriasis, or whole body erythroderma.
- Active infection or persistent fever of unknown origin. 5.) Major concurrent illness, which could worsen following treatment with DaclizumabTM.
- Any history of an un-treated neoplasm
Where it is running
- Rockefeller University Hospital — New York, New York, United States
- Rockefeller University — New York, New York, United States
- Rockefeller University — New York, New York, United States
Full record on ClinicalTrials.gov
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