Dynamic Light Scattering and Keratoscopy for Corneal Examination
Completed
Conditions studied: Corneal Diseases
In brief
This pilot study will examine the usefulness of a new instrument called the Dynamic Light Scattering (DLS) device for documenting and monitoring changes in the cornea, the front part of the eye where contact lenses are placed. The DLS device uses a low-intensity laser similar to that used in supermarket checkouts to measure the cloudiness of the cornea. The results of this study may lead to further investigations using DLS to discover the cause of corneal clouding and to develop treatments to prevent it. Healthy volunteers and patients with corneal clouding or opacification 18 years of age and older may be eligible for this study. Participants will have a standard eye examination, including a check of visual acuity and eye pressure. The retina will also be examined and photographs of the cornea may be taken. For the DLS test, the subject sits in front of the device and looks at a yellow-green target while the cloudiness of the cornea is measured. Subjects will be tested four times. The entire procedure takes less than 30 minutes.
Key facts
- Study ID
- NCT00050466
- Run by
- National Eye Institute (NEI)
- People needed
- 24
- Starts
- 2002-12-01
- Expected to finish
- 2005-09-01
- Last updated by the study team
- 2008-03-04
Who can join
Age: any. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Individuals greater than or equal to 18 years of age.
- Controls:
- Control subjects must have normal, clear corneas as determined by slit lamp biomicroscopy and central corneal thickness less than 0.55 mm centrally.
- Patients:
- Patients with corneal clouding and opacification.
You may not qualify if…
- To be eligible, participants must not satisfy the criterion below:
- Individuals who cannot cooperate or keep still for the DLS measurements.
Where it is running
- National Eye Institute (NEI) — Bethesda, Maryland, United States
Full record on ClinicalTrials.gov
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