HORIZON-PFT: Pivotal Fracture Trial

Completed · Phase 3

Conditions studied: Osteoporosis

In brief

HORIZON-PFT (Pivotal Fracture Trial) will study the effect of zoledronic acid, given once per year, on the treatment of osteoporosis in women past menopause. Hip and vertebral fractures are the most devastating consequences of osteoporosis. HORIZON-PFT is designed to determine the benefits of zoledronic acid in fracture reduction at both the hip and spine.

Key facts

Study ID

NCT00049829

Run by

Novartis Pharmaceuticals

People needed

7700

Starts

2002-01-01

Last updated by the study team

2011-11-02

Who can join

Age: 65 and older, up to 89. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female, 65-89 years old
• No history of severe liver, kidney or eye disease

You may not qualify if…

• Current bisphosphonate users such as Aredia® (pamidronate), Didronel® (etidronate), Fosamax® (alendronate), Actonel® (risedronate), Skelid® (tiludronate)
• Using hip protectors
• Other protocol-defined inclusion/exclusion criteria may apply.

Where it is running

• Arizona Arthritis Research — Paradise Valley, Arizona, United States
• Southern Arizona VA — Tucson, Arizona, United States
• University of Arkansas for Medical Science — Little Rock, Arkansas, United States
• Osteoporosis Medical Center — Beverly Hills, California, United States
• Orthopaedic Hospital — Los Angeles, California, United States
• The Foundation for Osteoporosis Research and Education — Oakland, California, United States
• University of California Davis- Gen Med Research — Sacramento, California, United States
• Osteoporosis Prevention Center — San Diego, California, United States
• Radiant Research- San Diego — San Diego, California, United States
• Diablo Clinical Research, Inc — Walnut Creek, California, United States
• Colorado Center for Bone Research — Lakewood, Colorado, United States
• Longmont Medical Research Network — Longmont, Colorado, United States
• Northeast Clinical Research — Hamden, Connecticut, United States
• Health Core — Newark, Delaware, United States
• CRA Research — Fort Lauderdale, Florida, United States
• Anchor Research Center — Naples, Florida, United States
• Sarasota Arthritis Center — Sarasota, Florida, United States
• Radiant — Stuart, Florida, United States
• Comprehensive Clinical Trials, LLC — West Palm Beach, Florida, United States
• Palm Beach Research Center — West Palm Beach, Florida, United States
• United Osteoporosis Centers (UOC) — Gainesville, Georgia, United States
• Northwestern University Center for Clinical Research — Chicago, Illinois, United States
• School of Medicine — Indianapolis, Indiana, United States
• Medical Specialists — Munster, Indiana, United States
• University of Alabama at Birmingham — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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