Open-Label Study of Efficacy and Safety of Recombinant Human N-acetylgalactosamine 4-sulfatase in Patients With MPS VI

Completed · Phase 2

Conditions studied: Mucopolysaccharidosis VI

In brief

The purpose of the study is evaluate the efficacy, safety, and pharmacokinetics of weekly intravenous infusions of 1 mg/kg recombinant human N-acetylgalactosamine 4-sulfatase (rhASB) in patients diagnosed with Mucopolysaccharidosis VI (MPS VI)

Key facts

Study ID

NCT00048711

Run by

BioMarin Pharmaceutical

Starts

2002-03-01

Expected to finish

2006-06-01

Last updated by the study team

2009-08-25

Who can join

Age: 5 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patient consent
• Patient must be five years of age or older
• Patient must have documented biochemical or genetic proof of MPS VI
• Patient must walk at least 1 meter, but less than 250 meters, in the first 6 minutes of the baseline 12-minute walk test
• If female of childbearing potential, patient must have a negative pregnancy test

You may not qualify if…

• Patient is under consideration for or has undergone a successful bone marrow transplant (BMT).
• Pregnant or lactating patient
• Patient has received an investigational drug within 30 days prior to study enrollment
• Patient has been previously treated with rhASB
• Patient has a medical condition, serious intercurrent illness, or other extenuating circumstance that may significantly confound study results or decrease study compliance
• Patient has a known hypersensitivity to rhASB or to components of the study drug
• History of cancer (except low grade and fully resolved skin malignancy)

Where it is running

• BioMarin Pharmaceutical Inc. — Novato, California, United States

Full record on ClinicalTrials.gov

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