National Lung Screening Trial (NLST) Screening

Completed · Phase 3

Conditions studied: Lung Cancer

In brief

RATIONALE: Effective screening tests should help doctors detect lung cancer early and plan curative treatment. It is not yet known whether low-dose helical computed tomography (LDCT) screening is more effective than chest radiography (CXR) screening in reducing death from lung cancer. PURPOSE: Randomized clinical trial to compare the effectiveness of LDCT scan with that of CXR in screening individuals who are at high risk for developing lung cancer.

Key facts

Study ID

NCT00047385

Run by

National Cancer Institute (NCI)

People needed

53454

Starts

2002-08-01

Expected to finish

2010-10-01

Last updated by the study team

2014-05-20

Who can join

Age: 55 and older, up to 74. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 55-74 years (pack-years = packs per day * years smoked)
• 30 or more pack-years of cigarette smoking history
• Former smokers: quit smoking within the previous 15 years
• Ability to lie on the back with arms raised over the head
• Signed informed consent form

You may not qualify if…

• Metallic implants or devices in the chest or back, such as pacemakers or Harrington fixation rods
• Treatment for, or evidence of, any cancer other than nonmelanoma skin cancer or carcinoma in situ (with the exception of transitional cell carcinoma in situ or bladder carcinoma in situ) in the 5 years prior to eligibility assessment
• History of lung cancer
• History of removal of any portion of the lung, excluding needle biopsy
• Requirement for home oxygen supplementation
• Participation in another cancer screening trial
• Participation in a cancer prevention study, other than a smoking cessation study
• Unexplained weight loss of more than 15 pounds in the 12 months prior to eligibility assessment
• Recent hemoptysis
• Pneumonia or acute respiratory infection treated with antibiotics in the 12 weeks prior to eligibility assessment
• Chest CT examination in the 18 months prior to eligibility assessment

Where it is running

• University of Alabama at Birmingham — Birmingham, Alabama, United States
• Univeristy of California, San Diego — La Jolla, California, United States
• Jonsson Comprehensive Cancer Center, UCLA — Los Angeles, California, United States
• University of Colorado Denver — Denver, Colorado, United States
• Georgetown University Medical Center — Washington D.C., District of Columbia, United States
• Mayo Clinic — Jacksonville, Florida, United States
• H. Lee Moffitt Cancer Center and Research Institute — Tampa, Florida, United States
• Emory University School of Medicine — Atlanta, Georgia, United States
• Pacific Health Research & Education Institute — Honolulu, Hawaii, United States
• Northwestern University — Chicago, Illinois, United States
• University of Iowa — Iowa City, Iowa, United States
• Jewish Hopsital Heart and Lung Institute — Louisville, Kentucky, United States
• Ochsner Medical Foundation Hospital — New Orleans, Louisiana, United States
• Johns Hopkins University — Baltimore, Maryland, United States
• Brigham and Women's Hospital — Boston, Massachusetts, United States
• Beth Israel Deaconess Medical Center — Boston, Massachusetts, United States
• University of Michigan Comprehensive Cancer Center — Ann Arbor, Michigan, United States
• Henry Ford Health System — Detroit, Michigan, United States
• University of Minnesota School of Public Health — Minneapolis, Minnesota, United States
• Mayo Clinic Cancer Center — Rochester, Minnesota, United States
• Washington University School of Medicine — St Louis, Missouri, United States
• Dartmouth-Hitchcock Medical Center — Lebanon, New Hampshire, United States
• Cancer Institute of New Jersey at Hamilton — Hamilton, New Jersey, United States
• Wake Forest University — Winston-Salem, North Carolina, United States
• St Elizabeth Health Center — Youngstown, Ohio, United States

Full record on ClinicalTrials.gov

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