Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors
Completed · Phase 2
Conditions studied: Brain Tumor, Central Nervous System Tumors, Childhood Germ Cell Tumor
In brief
RATIONALE: Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die. Giving a chemotherapy drug before surgery may shrink the tumor so that it is no longer present by conventional imaging and tumor markers from serum and cerebrospinal fluid. Radiation therapy uses high-energy x-rays to damage tumor cells. Peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. Combining different types of therapy may kill more tumor cells. PURPOSE: This Phase II trial is studying how well neoadjuvant chemotherapy with or without surgery and with or without high dose chemotherapy and peripheral stem cell transplantation, can increase response rates prior to radiation therapy and increase progression free and overall surviving patients with newly diagnosed intracranial germ cell tumors.
Key facts
- Study ID
- NCT00047320
- Run by
- Children's Oncology Group
- People needed
- 104
- Starts
- 2004-01-01
- Expected to finish
- 2009-02-01
- Last updated by the study team
- 2018-02-14
Who can join
Age: 3 and older, up to 24. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Phoenix Children's Hospital — Phoenix, Arizona, United States
- Arkansas Cancer Research Center at University of Arkansas for Medical Sciences — Little Rock, Arkansas, United States
- Southern California Permanente Medical Group — Downey, California, United States
- Loma Linda University Cancer Institute at Loma Linda University Medical Center — Loma Linda, California, United States
- Jonathan Jaques Children's Cancer Center at Miller Children's Hospital — Long Beach, California, United States
- Childrens Hospital Los Angeles — Los Angeles, California, United States
- Children's Hospital Central California — Madera, California, United States
- Children's Hospital and Research Center Oakland — Oakland, California, United States
- Children's Hospital of Orange County — Orange, California, United States
- Sutter Cancer Center — Sacramento, California, United States
- Rady Children's Hospital - San Diego — San Diego, California, United States
- UCSF Helen Diller Family Comprehensive Cancer Center — San Francisco, California, United States
- Stanford Cancer Center — Stanford, California, United States
- Carole and Ray Neag Comprehensive Cancer Center at the University of Connecticut Health Center — Farmington, Connecticut, United States
- Alfred I. duPont Hospital for Children — Wilmington, Delaware, United States
- Children's National Medical Center — Washington D.C., District of Columbia, United States
- Lee Cancer Care of Lee Memorial Health System — Fort Myers, Florida, United States
- University of Florida Shands Cancer Center — Gainesville, Florida, United States
- Nemours Children's Clinic — Jacksonville, Florida, United States
- University of Miami Sylvester Comprehensive Cancer Center - Miami — Miami, Florida, United States
- Miami Children's Hospital — Miami, Florida, United States
- Florida Hospital Cancer Institute at Florida Hospital Orlando — Orlando, Florida, United States
- Sacred Heart Cancer Center at Sacred Heart Hospital — Pensacola, Florida, United States
- All Children's Hospital — St. Petersburg, Florida, United States
- Lurleen Wallace Comprehensive Cancer at University of Alabama - Birmingham — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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