Chemotherapy and Radiation Therapy With or Without Surgery in Treating Patients With Head and Neck Cancer
Completed · Phase 3
Conditions studied: Head and Neck Cancer
In brief
RATIONALE: Radiation therapy (RT) uses high-energy x-rays to damage tumor cells. Giving radiation therapy in different ways and combining it with chemotherapy before surgery may kill more tumor cells. It is not yet known which radiation therapy regimen combined with chemotherapy with or without surgery is more effective for head and neck cancer. PURPOSE: Randomized phase III trial to compare two different radiation therapy regimens combined with cisplatin with or without surgery in treating patients who have stage III or stage IV head and neck cancer.
Key facts
- Study ID
- NCT00047008
- Run by
- Radiation Therapy Oncology Group
- People needed
- 743
- Starts
- 2002-07-01
- Expected to finish
- 2022-05-20
- Last updated by the study team
- 2023-07-07
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Mobile Infirmary Medical Center — Mobile, Alabama, United States
- Foundation for Cancer Research and Education — Phoenix, Arizona, United States
- CCOP - Mayo Clinic Scottsdale Oncology Program — Scottsdale, Arizona, United States
- Scottsdale Healthcare - Shea — Scottsdale, Arizona, United States
- Virginia G. Piper Cancer Center at Scottsdale Healthcare - Osborn — Scottsdale, Arizona, United States
- Providence Saint Joseph Medical Center - Burbank — Burbank, California, United States
- Saint Rose Hospital — Hayward, California, United States
- Cancer Care Consultants Medical Associates at Daniel Freeman Memorial Hospital — Inglewood, California, United States
- Valley Memorial Hospital — Livermore, California, United States
- Loma Linda University Cancer Institute at Loma Linda University Medical Center — Loma Linda, California, United States
- USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
- Providence Holy Cross Cancer Center — Mission Hills, California, United States
- Highland General Hospital — Oakland, California, United States
- CCOP - Bay Area Tumor Institute — Oakland, California, United States
- Summit Medical Center — Oakland, California, United States
- Pomona Valley Hospital Medical Center — Pomona, California, United States
- Radiological Associates of Sacramento Medical Group, Inc. — Sacramento, California, United States
- University of California Davis Cancer Center — Sacramento, California, United States
- Naval Medical Center - San Diego — San Diego, California, United States
- J.C. Robinson, M.D. Regional Cancer Center — San Pablo, California, United States
- Memorial Hospital Cancer Center — Colorado Springs, Colorado, United States
- University of Colorado Cancer Center at University of Colorado Health Sciences Center — Denver, Colorado, United States
- Beebe Medical Center — Lewes, Delaware, United States
- CCOP - Christiana Care Health Services — Newark, Delaware, United States
- Comprehensive Cancer Center at University of Alabama at Birmingham — Birmingham, Alabama, United States
Full record on ClinicalTrials.gov
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