The Effect of Short-Term Statins and NSAIDs on Levels of Beta-Amyloid, a Protein Associated With Alzheimer's Disease

Completed · Phase 4

Conditions studied: Alzheimer Disease

In brief

The purpose of this study is to determine whether short-term use of the drugs ibuprofen and lovastatin affects levels of a protein called beta-amyloid in people who are at risk for developing Alzheimer's Disease (AD).

Key facts

Study ID

NCT00046358

Run by

National Institute of Mental Health (NIMH)

People needed

50

Starts

2002-09-01

Expected to finish

2005-08-01

Last updated by the study team

2008-03-04

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Normal volunteer over the age of 18
• Cognitively within normal limits at baseline evaluation
• Previously evaluated in Protocol 95-M-0096
• Women of child-bearing potential will be advised not to become pregnant during the treatment period

You may not qualify if…

• Known allergies to lovastatin or ibuprofen
• Use of regular dosing of NSAID or statin during the previous month
• Concurrent use of cyclosporine, itraconazole, ketoconazole, gemfibrozil, niacin, erythromycin, clarithromycin, HIV protease inhibitors or nefazodone because of possible drug interactions with lovastatin.
• Women who are currently pregnant
• Concurrent use of anticoagulants, aspirin, beta-adrenergic agents, cimetidine, digoxin and oral hypoglycemics because of possible drug interactions with ibuprofen.
• Peptic ulcer disease by history
• Autoimmune disease by history

Where it is running

• National Institute of Mental Health (NIMH) — Bethesda, Maryland, United States

Full record on ClinicalTrials.gov

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