Optimizing Electroconvulsive Therapy for Depression
Completed · Phase 4 · Has a placebo group
Conditions studied: Depression, Depressive Disorder, Bipolar Disorder
In brief
This study will evaluate the effectiveness of electroconvulsive therapy (ECT) administered with medication for the treatment of a major depressive episode (unipolar or bipolar) and will compare two types of ECT.
Key facts
- Study ID
- NCT00045916
- Run by
- New York State Psychiatric Institute
- People needed
- 340
- Starts
- 2001-02-01
- Expected to finish
- 2006-12-01
- Last updated by the study team
- 2013-08-13
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Major depressive episode (unipolar or bipolar)
- Pre-ECT score of 20 or higher on Hamilton Rating Scale for Depression
- Able to withdraw psychotropic drugs (up to 3 mg/day lorazepam allowed)
- ECT indicated
You may not qualify if…
- Schizophrenia, schizoaffective disorder, or other psychosis
- Amnestic disorder, dementia, or delirium
- Pregnancy
- Epilepsy
- Current alcohol or substance abuse or dependence
- CNS disease or brain injury not associated with psychotropic drug exposure
- ECT in the past 6 months
- Medical contraindication for treatment with either nortriptyline or venlafaxine, including allergy to amitriptyline, nortriptyline, or venlafaxine; narrow angle glaucoma; sinus node disease; bundle branch disease; myocardial infarction; coronary artery bypass or angioplasty; or angina
- Type I antiarrhythmic medication
- Supine blood pressure >= 170 mmHg systolic or >= 105 mmHg diastolic at 3 readings over 2 days
Where it is running
- Washington University — St Louis, Missouri, United States
- New York State Psychiatric Institute at Columbia University — New York, New York, United States
- Wake Forest University — Winston-Salem, North Carolina, United States
- Western Psychiatric Institute and Clinic — Pittsburgh, Pennsylvania, United States
Full record on ClinicalTrials.gov
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