Treatment Outcome of Vascular Depression

Completed

Conditions studied: Depressive Disorder, Depression

In brief

This 12-week study will evaluate the effectiveness of sertraline (Zoloft®) for treatment of depression associated with small vascular lesions in the brain (vascular depression).

Key facts

Study ID

NCT00045773

Run by

University of Pennsylvania

People needed

208

Starts

2001-04-01

Expected to finish

2006-04-01

Last updated by the study team

2017-10-31

Who can join

Age: 60 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Ages 60+
• DSM-IV criteria for MDD
• Hamilton Depression Rating Scale score >18
• No MRI contraindications, e.g. foreign metallic implants, pacemaker
• Medication free of any psychotropic drug except as otherwise noted for set washout period (see D.2.1)
• Mini Mental Status Exam score <21
• No unstable medical disorders (requiring immediate medical attention)
• Ability to give informed consent
• English speaking

You may not qualify if…

• Age <60
• Does not meet DSM-IV criteria for MDD
• Hamilton Depression Rating Scale score <18
• MRI contraindications e.g. foreign metallic implants, pacemaker
• Psychotropic drug use other than zolpidem and lorazepam, prn within 2 weeks of entry
• Mini Mental Status Exam score >21, or known primary neurological disorders including Dementia of the Alzheimer type, Parkinson's Disease, multiple sclerosis, seizure disorder.
• Unstable medical disorders, uncorrected hypothyroidism, or any condition that in the investigators opinion makes the patients unsuitable for a trial
• Cannot give informed consent
• Does not speak English

Where it is running

• Washington University School of Medicine — St Louis, Missouri, United States
• Duke University Medical Center — Durham, North Carolina, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.