Total-Body Irradiation, Fludarabine, and Peripheral Stem Cell Transplantation in Treating Patients With Hematologic Cancer

Completed · Phase 2

Conditions studied: Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm, Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Diseases

In brief

RATIONALE: Radiation therapy uses high-energy x-rays to damage cancer cells. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining chemotherapy with donor peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combining total-body irradiation with fludarabine and donor peripheral stem cell transplantation in treating patients who have hematologic cancer.

Key facts

Study ID

NCT00044954

Run by

University of Texas Southwestern Medical Center

Starts

1999-11-01

Expected to finish

2006-11-01

Last updated by the study team

2019-09-17

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

Where it is running

• Rocky Mountain Cancer Centers - Denver Midtown — Denver, Colorado, United States
• Florida Hospital Cancer Institute — Orlando, Florida, United States
• Blood and Marrow Transplant Group of Georgia — Atlanta, Georgia, United States
• Holden Comprehensive Cancer Center at University of Iowa — Iowa City, Iowa, United States
• Kansas City Cancer Centers - Central — Kansas City, Missouri, United States
• Cancer Center at Hackensack University Medical Center — Hackensack, New Jersey, United States
• St. Joseph's Hospital and Medical Center — Paterson, New Jersey, United States
• James P. Wilmot Cancer Center at University of Rochester Medical Center — Rochester, New York, United States
• Cancer Institute at Oregon Health and Science University — Portland, Oregon, United States
• Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center — Nashville, Tennessee, United States
• Simmons Cancer Center at University of Texas Southwestern Medical Center - Dallas — Dallas, Texas, United States
• Texas Transplant Institute — San Antonio, Texas, United States
• Massey Cancer Center at Virginia Commonwealth University — Richmond, Virginia, United States
• University of Wisconsin Comprehensive Cancer Center — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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