Bupropion as a Smoking Cessation Aid in Alcoholics

Completed · Phase 4

Conditions studied: Alcoholism, Smoking

In brief

The purpose of this study is to test the use of time-released bupropion (Wellbutrin) in patients receiving treatment for alcohol abuse/dependence as an aid to stop smoking. Patients will receive either a time-released bupropion or placebo. Both groups will receive nicotine replacement therapy during the 9 week study. A final followup assessment will be conducted 6 months from the start of treatment.

Key facts

Study ID

NCT00044434

Run by

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

People needed

200

Starts

2002-05-01

Expected to finish

2005-04-01

Last updated by the study team

2008-01-29

Who can join

Age: 25 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Currently a patient in the Omaha VA Medical Center, Substance Abuse Treatment Center (SATC) or at Catholic Charities Campus for Hope.
• Have a diagnosis of alcohol abuse or alcohol dependence.
• Smoke 20 or more cigarettes/day (may also smoke pipes/cigars).
• Be interested in quitting smoking.
• Provide name, addresses, and phone numbers of at least two individuals who can provide information on their alcohol, nicotine, and other drug use during the follow-up period.
• If female, patient must a) be of non-childbearing potential, b) have a negative pregnancy test, c) sign a document stating they do not plan on becoming pregnant during the study.
• Agree to sign informed consent.
• Able to read and understand study-related forms and procedures.

You may not qualify if…

• Advanced cardiac, pulmonary, renal, or liver disease.
• History of seizures.
• History of brain tumor or significant head trauma.
• History of bulimia or anorexia nervosa.
• Current major depressive disorder or past history of panic disorders, schizophrenia, or bipolar affective disorder.
• Using psychoactive drugs.
• Receiving treatment with medications that lower seizure thresholds.
• Use of an investigational drug in any study in the past four weeks.
• Currently using any asthma medication.
• Used time-released bupropion in the past 12 months.
• Currently using any other treatments to stop smoking.

Where it is running

• VA/Nebraska/Western Iowa Health Care System — Omaha, Nebraska, United States

Full record on ClinicalTrials.gov

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