The Effect of LY333531 on Protein in the Urine in Patients With Type 2 Diabetes

Completed · Phase 2

Conditions studied: Diabetic Nephropathy

In brief

The purpose of this study are to determine 1) Whether Ly333531 can reduce urinary albumin/creatinine excretion in patients with Type II diabetes and persistent albuminuria 2) Whether LY333531 reduces urinary TGF-B, 3) the safety of LY333531 and any side effects that may be associated with it.

Key facts

Study ID

NCT00044148

Run by

Chromaderm, Inc.

Starts

2002-07-16

Expected to finish

2004-04-28

Last updated by the study team

2017-02-01

Who can join

Age: 30 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Type 2 diabetes mellitus
• Greater than or equal to 30 years of age
• Albumin to Creatinine ratio (greater than 200 mg/g and less than 2000 mg/g) 4)Without language barrier.

You may not qualify if…

• Serum Creatinine greater than 2.0 mg/dl males or greater than 1.7 mg/dl females
• B/P greater than 150 systolic and greater than 90 diastolic
• Hemoglobin Alc greater than 11%
• Liver Function Tests 2 times upper limit of normal
• Poor medical or psychiatric risk.

Where it is running

• Study site — La Jolla, California, United States
• Study site — Walnut Creek, California, United States
• Study site — Jacksonville, Florida, United States
• Study site — Atlanta, Georgia, United States
• Study site — Chicago, Illinois, United States
• Study site — Lexington, Kentucky, United States
• Study site — Baltimore, Maryland, United States
• Study site — Waltham, Massachusetts, United States
• Study site — Minneapolis, Minnesota, United States
• Study site — St Louis, Missouri, United States
• Study site — New York, New York, United States
• Study site — Greenville, North Carolina, United States
• Study site — Dallas, Texas, United States
• Study site — Seattle, Washington, United States
• Study site — Spokane, Washington, United States

Full record on ClinicalTrials.gov

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