Study Of Two Non-Myeloablative Stem Cell Transplant Strategies For Low-Grade Lymphoma And CLL
Stopped early · Phase 2
Conditions studied: Leukemia, Lymphoma
In brief
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells. Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy or radiation therapy. Sometimes the transplanted cells are rejected by the body's normal tissues. Cyclosporine, mycophenolate mofetil, methotrexate, and tacrolimus may prevent this from happening. PURPOSE: Randomized phase II trial to compare the effectiveness of fludarabine plus total-body irradiation with that of combination chemotherapy followed by donor peripheral stem cell transplantation in treating patients who have relapsed non-Hodgkin's lymphoma or chronic lymphocytic leukemia.
Key facts
- Study ID
- NCT00041288
- Run by
- University of Texas Southwestern Medical Center
- People needed
- 10
- Starts
- 2001-10-01
- Expected to finish
- 2003-01-01
- Last updated by the study team
- 2020-04-10
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Rocky Mountain Cancer Centers — Denver, Colorado, United States
- Delaware Clinical & Laboratory Physicians — Newark, Delaware, United States
- Florida Hospital Cancer Institute — Orlando, Florida, United States
- H. Lee Moffitt Cancer Center and Research Institute — Tampa, Florida, United States
- Blood and Marrow Transplant Group of Georgia — Atlanta, Georgia, United States
- Holden Comprehensive Cancer Center — Iowa City, Iowa, United States
- University of Missouri Kansas City School of Medicine — Kansas City, Missouri, United States
- Hackensack University Medical Center — Hackensack, New Jersey, United States
- St. Joseph's Hospital and Medical Center — Paterson, New Jersey, United States
- James P. Wilmot Cancer Center — Rochester, New York, United States
- Oregon Cancer Institute — Portland, Oregon, United States
- University of Pennsylvania Cancer Center — Philadelphia, Pennsylvania, United States
- Kimmel Cancer Center of Thomas Jefferson University - Philadelphia — Philadelphia, Pennsylvania, United States
- Vanderbilt-Ingram Cancer Center — Nashville, Tennessee, United States
- Simmons Cancer Center - Dallas — Dallas, Texas, United States
- Texas Transplant Institute — San Antonio, Texas, United States
- Massey Cancer Center — Richmond, Virginia, United States
- University of Wisconsin Comprehensive Cancer Center — Madison, Wisconsin, United States
- Medical College of Wisconsin — Milwaukee, Wisconsin, United States
- Ottawa Regional Cancer Centre — Ottawa, Ontario, Canada
- Princess Margaret Hospital — Toronto, Ontario, Canada
- University of Toronto — Toronto, Ontario, Canada
- Hopital du Saint-Sacrament, Quebec — Québec, Quebec, Canada
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.