Four Versus Six Cycles of Cyclophosphamide/Doxorubicin or Paclitaxel in Adjuvant Breast Cancer

Completed · Phase 3

Conditions studied: Breast Cancer

In brief

This randomized phase III trial studies cyclophosphamide and doxorubicin hydrochloride compared with paclitaxel as adjuvant therapy in treating breast cancer in women with 0-3 positive axillary lymph nodes. Giving additional cancer treatment after surgery may help to lower the risk that the cancer will come back (adjuvant therapy). Drugs used in chemotherapy, such as cyclophosphamide, doxorubicin hydrochloride, and paclitaxel, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether the standard adjuvant therapy of cyclophosphamide and doxorubicin hydrochloride is more effective than paclitaxel in treating women with breast cancer

Key facts

Study ID

NCT00041119

Run by

Alliance for Clinical Trials in Oncology

People needed

3871

Starts

2002-05-01

Expected to finish

2014-06-01

Last updated by the study team

2017-05-18

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: not accepted.

Where it is running

• UAB Comprehensive Cancer Center — Birmingham, Alabama, United States
• Providence Cancer Center at Providence Hospital — Mobile, Alabama, United States
• Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital — Fairbanks, Alaska, United States
• Mayo Clinic Scottsdale — Scottsdale, Arizona, United States
• Hembree Mercy Cancer Center at St. Edward Mercy Medical Center — Fort Smith, Arkansas, United States
• Alta Bates Summit Comprehensive Cancer Center — Berkeley, California, United States
• Peninsula Medical Center — Burlingame, California, United States
• East Bay Radiation Oncology Center — Castro Valley, California, United States
• Valley Medical Oncology Consultants - Castro Valley — Castro Valley, California, United States
• Valley Medical Oncology — Fremont, California, United States
• Washington Township Hospital — Fremont, California, United States
• California Cancer Center - Woodward Park Office — Fresno, California, United States
• Cancer Care Associates — Fresno, California, United States
• Marin Cancer Institute at Marin General Hospital — Greenbrae, California, United States
• Rebecca and John Moores UCSD Cancer Center — La Jolla, California, United States
• USC/Norris Comprehensive Cancer Center and Hospital — Los Angeles, California, United States
• Contra Costa Regional Medical Center — Martinez, California, United States
• Tibotec Therapeutics - Division of Ortho Biotech Products, LP — Marysville, California, United States
• Memorial Medical Center — Modesto, California, United States
• Highland General Hospital — Oakland, California, United States
• Alta Bates Summit Medical Center - Summit Campus — Oakland, California, United States
• Bay Area Breast Surgeons, Incorporated — Oakland, California, United States
• CCOP - Bay Area Tumor Institute — Oakland, California, United States
• Tom K Lee, Incorporated — Oakland, California, United States
• Regional Medical Center — Anniston, Alabama, United States

Full record on ClinicalTrials.gov

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