Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADVISE)

Completed · Has a placebo group

Conditions studied: Alzheimer Disease

In brief

The Prevention of Alzheimer's Disease by Vitamin E and Selenium (PREADVISE) prevention trial is an important addition to the Selenium and Vitamin E Cancer Prevention Trial (SELECT). As a prevention trial, PREADVISE is trying to find out if taking selenium and/or Vitamin E supplements can help to prevent memory loss and dementia such as Alzheimer's disease.

Key facts

Study ID

NCT00040378

Run by

Frederick Schmitt

People needed

4246

Starts

2002-05-01

Expected to finish

2016-08-01

Last updated by the study team

2018-03-14

Who can join

Age: 60 and older, up to 90. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Participating in SELECT Prevention study;
• 62 years or older if other ethnic origin, or 60 years or older if African-American or Hispanic;
• General good health with no neurological or psychiatric illness.

You may not qualify if…

• The SELECT doctors or staff will review the PREADVISE applicants' medical history and drugs to verify that they have no condition(s) that would exclude them from this study. The participant must not have any of the following neurological conditions based on self report (were told by a physician):
• Alzheimer's disease, or any other form of dementia such as Pick's disease, dementia with Lewy bodies, frontotemporal dementia, vascular dementia, significant cognitive and motor impairment from a stroke or corticobasal degeneration;
• Huntington's disease, epilepsy, Parkinson's disease, brain tumor, multiple sclerosis, manic-depressive disorder, or schizophrenia;
• The participant must not have had a head injury with prolonged loss of consciousness (over 30 minutes) within the past five years;
• The participant must not have a current alcohol or substance abuse diagnosis, or must have been treatment free for the past 24 months;
• The participant must not have had a diagnosis of depression or anxiety disorder in the past 4 months and must not currently be under treatment for depression or anxiety disorder. [A participant who was previously diagnosed with depression or anxiety disorder but completed treatment more than four months ago is eligible.];
• The participant must not currently use of any of the following medications: Aricept, Cognex, Exelon, Reminyl, or Hydergine;
• The participant must not have blindness, deafness, language difficulties or any other disability that may prevent completion of the memory screen.

Where it is running

• Alaska Regional Hospital — Anchorage, Alaska, United States
• Providence Alaska Medical Center — Anchorage, Alaska, United States
• University of California, San Diego - Chula Vista — Chula Vista, California, United States
• Glendale Memorial Hospital — Glendale, California, United States
• University of California, San Diego — La Jolla, California, United States
• VA Medical Center — Loma Linda, California, United States
• VAMC Long Beach — Long Beach, California, United States
• Northridge Hospital Medical Center — Northridge, California, United States
• Santa Rosa Memorial Hospital Regional CCOP — Santa Rosa, California, United States
• LABIOMED (Los Angeles Biomedical) Research Institute at Harbor-UCLA Medical Center — Torrance, California, United States
• Lionel B. Katchem — Upland, California, United States
• Rocky Mountain CC/Poudre Valley Hospital — Fort Collins, Colorado, United States
• Sibley Memorial Hospital — Washington D.C., District of Columbia, United States
• George Washington University Medical Center — Washington D.C., District of Columbia, United States
• DC United MBCCOP — Washington D.C., District of Columbia, United States
• Baptist Medical Center — Jacksonville, Florida, United States
• Kaiser Southeast Permanente Medical Group — Tucker, Georgia, United States
• Bliss Cancer Center/McFarland Clinic/Mary Greely MC — Ames, Iowa, United States
• Cedar Rapids CCOP — Cedar Rapids, Iowa, United States
• Genesis Medical Center — Davenport, Iowa, United States
• Iowa Oncology Research Association — Des Moines, Iowa, United States
• Siouxland Hematology-Oncology Associates — Sioux City, Iowa, United States
• University of Kansas Medical Center — Kansas City, Kansas, United States
• Stormont-Vail Health Care/Cotton O'Neil Clinic — Topeka, Kansas, United States
• University of Alabama at Birmingham Preventive Medicine — Birmingham, Alabama, United States

Full record on ClinicalTrials.gov

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