Evaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes Mellitus Treated With a Sulfonylurea

Completed · Phase 3 · Has a placebo group

Conditions studied: Diabetes Mellitus, Non-Insulin-Dependent

In brief

This is a multicenter, randomized, blinded, placebo-controlled study to assess the effects on glucose control of AC2993 as compared to placebo in patients with type 2 diabetes. Patients will be randomized into one of two AC2993 treatment arms or to placebo treatment and will continue with their required existing diabetes medication (sulfonylurea) throughout the study.

Key facts

Study ID

NCT00039026

Run by

AstraZeneca

People needed

377

Starts

2002-02-01

Expected to finish

2003-08-01

Last updated by the study team

2015-02-24

Who can join

Age: 16 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects with Type 2 diabetes mellitus
• Treated with a sulfonylurea at defined doses for at least 3 months prior to screening
• BMI= 27-45 kg/m2
• HbA1c value between 7.5% and 11%

You may not qualify if…

• Treated with oral anti-diabetic medications other than a sulfonylurea within 3 months of screening
• Patients treated previously with AC2993
• Patients presently treated with insulin

Where it is running

• Parkway Medical Center — Birmingham, Alabama, United States
• Alabama Clinical Therapeutics — Birmingham, Alabama, United States
• Eclectic Family Care — Eclectic, Alabama, United States
• Winston Physician Services — Haleyville, Alabama, United States
• Simon Williamson Clinic — Hueytown, Alabama, United States
• Extended Arm Physicians/ Southern Drug — Montgomery, Alabama, United States
• Southern Drug Research Network — Tallassee, Alabama, United States
• Clinic of Physicians and Surgeons, Ltd. — Mesa, Arizona, United States
• ANA Ventures, LLC — Mesa, Arizona, United States
• Lovelace Scientific Resources-Phoenix — Phoenix, Arizona, United States
• Physicians at the Peak — Phoenix, Arizona, United States
• Advanced Clinical Therapeutics — Tucson, Arizona, United States
• CAVHS — Little Rock, Arkansas, United States
• Physicians Group Research Clinic, LLC — Little Rock, Arkansas, United States
• Advanced Clinical Research Institute — Anaheim, California, United States
• Mitchell Research Group, Inc. — Bakersfield, California, United States
• William Zigrang, M.D. — Burlingame, California, United States
• International Clinical Research Network — Chula Vista, California, United States
• Arrowhead Regional Medical Center — Colton, California, United States
• East Bay Clinical Trial Center — Concord, California, United States
• Valley Research — Fresno, California, United States
• Tushar Modi, M.D. — Modesto, California, United States
• Elke Jost-Vu, M.D. — Rancho Mirage, California, United States
• Comprehensive Diabetes-Endocrine Medical Associates — Redwood City, California, United States
• Pinnacle Research Group — Anniston, Alabama, United States

Full record on ClinicalTrials.gov

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