Effectiveness of ABT-378/Ritonavir Plus Lamivudine Plus Efavirenz Plus Tenofovir DF in HIV-Infected Patients

Completed · Phase 2

Conditions studied: HIV Infections

In brief

The purpose of this study is to see if a novel 4-drug anti-HIV combination can suppress the growth of HIV in patients infected with the virus.

Key facts

Study ID

NCT00038220

Run by

Abbott

People needed

40

Starts

2000-07-01

Last updated by the study team

2006-07-27

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Have HIV Infection.
• Age 18 to 65 years old.
• Show no signs of recent illness other than HIV infection.
• Agree to use a barrier method of birth control during the study and for 30 days after study.

You may not qualify if…

• Are unable to follow study requirements (in the opinion of the investigator).
• Are pregnant or breast-feeding.
• Are unable to take medications by mouth.
• Have chronic nausea or vomiting.
• Have cancer other than Kaposi's sarcoma or basal cell carcinoma.
• Have active, serious infections (other than HIV) requiring antibiotic injections within 15 days prior to screening.
• Are taking any medications that are not allowed with ABT-378/r and efavirenz.
• Are taking or have taken any other experimental drugs, antiretroviral drugs, or drugs that affect the immune system within 30 days of start of study without consent of the medical monitor.
• Are receiving or have received radiation therapy within 30 days of start of study without consent of the medical monitor.
• Have a history of drug abuse or mental illness that would prevent the patient from following the protocol requirements.
• Have a history of kidney or bone disease.

Where it is running

• Aaron Diamond AIDS Research Center - Rockefeller University — New York, New York, United States

Full record on ClinicalTrials.gov

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