Reversal of Ventricular Remodeling With Toprol-XL

Completed · Phase 3 · Has a placebo group

Conditions studied: Heart Failure, Congestive

In brief

The purpose of this study is to determine whether treatment with Toprol-XL for 12 months in asymptomatic heart failure subjects will improve their heart structure and thus prevent the progression to symptomatic disease.

Key facts

Study ID

NCT00038077

Run by

AstraZeneca

People needed

300

Starts

2001-08-01

Expected to finish

2003-09-01

Last updated by the study team

2010-11-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of stable asymptomatic heart failure.
• Documented ejection fraction less than 0.40.
• Must be able to comply with all study procedures.

You may not qualify if…

• Taken B-blocker therapy for longer than 1 week within 6 months prior to randomization.
• Have heart problems that would not allow B-blocker therapy.
• Receiving B-blockers therapy for any medical reason including topical B-blockers that might cause systemic absorption (e.g., glaucoma).
• Undergone certain heart surgeries, such as, prior heart transplant or cardiomyoplasty.
• Have certain heart diseases.
• Pregnant or breast feeding.
• Unlikely to survive.

Where it is running

• Study site — Birmingham, Alabama, United States
• Study site — Mobile, Alabama, United States
• Study site — Little Rock, Arkansas, United States
• Study site — Los Angeles, California, United States
• Study site — Northridge, California, United States
• Study site — Redondo Beach, California, United States
• Study site — Riverside, California, United States
• Research Site — Farmington, Connecticut, United States
• Study site — Clearwater, Florida, United States
• Study site — Melbourne, Florida, United States
• Study site — Vero Beach, Florida, United States
• Study site — Augusta, Georgia, United States
• Study site — Indianapolis, Indiana, United States
• Study site — Jeffersonville, Indiana, United States
• Study site — Edgewood, Kentucky, United States
• Study site — New Orleans, Louisiana, United States
• Study site — Shreveport, Louisiana, United States
• Study site — Auburn, Maine, United States
• Study site — Baltimore, Maryland, United States
• Study site — Salisbury, Maryland, United States
• Study site — Boston, Massachusetts, United States
• Study site — Saint Charles, Missouri, United States
• Study site — St Louis, Missouri, United States
• Study site — Omaha, Nebraska, United States
• Study site — Albuquerque, New Mexico, United States

Full record on ClinicalTrials.gov

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