Assessment of Head and Neck Tumor Hypoxia Using 18F-Fluoromisonidazole

Withdrawn before enrolling · Not applicable

Conditions studied: Squamous Cell Carcinoma, Head and Neck Neoplasms, Metastases, Neoplasm

In brief

The purpose of this clinical research study is to answer the following questions using 18F-fluoromisonidazole as an imaging agent: 1. Do cells exist in human tumors that are at very low oxygen levels (hypoxic cells)? 2. If hypoxic cells exist in human tumors, do they effect the ability of radiotherapy to control human tumors? 3. Can Positron Emission Tomography (PET scanning) detect hypoxic cells in human tumors?

Key facts

Study ID

NCT00038038

Run by

M.D. Anderson Cancer Center

People needed

0

Starts

1994-01-01

Expected to finish

2003-06-01

Last updated by the study team

2012-08-01

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically proven squamous cell carcinoma of head and neck wth metastatic neck nodes greater than or equal to 2cm
• Karnofsky performance status greater or equal to 60%

You may not qualify if…

• No prior irradiation or surgery to head/neck area
• No prior chemotherapy within 1 month of participation and have recovered from associated related effects
• Not pregnant
• Any intercurrent medical or physiologic disorder which would prevent informed consent
• Underlying medical problems which would compromise technical ability to deliver a "standard course" of radiation therapy
• Patients with PT or PTT over 1.5 times normal

Where it is running

• University of Texas M. D. Anderson Cancer Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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