A Study Of Deoxycoformycin(DCF)/Pentostatin In Lymphoid Malignancies
Completed · Phase 2
Conditions studied: Peripheral T-cell Lymphoma, Cutaneous T-cell Lymphoma, Chronic Lymphocytic Leukemia
In brief
The purpose of this study is to determine the side effects and antitumor response of patients with lymphoid malignancies to Deoxycoformycin (DCF)/Pentostatin.
Key facts
- Study ID
- NCT00038025
- Run by
- M.D. Anderson Cancer Center
- People needed
- 60
- Starts
- 1994-09-06
- Expected to finish
- 2006-11-29
- Last updated by the study team
- 2018-11-16
Who can join
Age: 16 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Histologic proof of lymphoid malignancy with an expected complete response rate of less than 20 percent OR have failed at least one prior therapy.
- No chemotherapy within 3 weeks of entry into study and must have recovered from acute toxic effects of prior therapy.
- Life expectancy of at least 12 weeks.
- Performance status equal to or less than Zubrod 2.
- Signed informed consent.
- Patients with measurable disease.
- Age at least 16 years.
- Adequate bone marrow function (unless involvement of bone marrow by lymphoma) defined as AGC greater than 1500 and platelet count greater than 100,000.
- Adequate hepatic function with a bilirubin less than or equal to 1.5 mg % and SGPT less than or equal to 4 times the upper limits of normal.
- Adequate renal function defined as serum creatine less than or equal to 1.5 mg %.
You may not qualify if…
- No serious intercurrent illness.
- Adequate contraception (if applicable).
- NO patients with significant cardiac disease, i.e. New York Heart Association (NYHA) class III or IV.
- NO experimental clinical trial within 3 weeks of study entry.
- NO patients with active CNS disease.
- Full recovery from any prior surgical treatment.
- NO active active infections.
Where it is running
- M. D. Anderson Cancer Center — Houston, Texas, United States
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.