Brain Imaging and Retreatment Study of Persistent Lyme Disease
Completed · Phase 2
Conditions studied: Lyme Disease, Lyme Neuroborreliosis
In brief
The purpose of this study is to determine whether patients with persistent memory problems after Lyme disease benefit from an additional longer course of IV antibiotic therapy; to use modern brain imaging technology to determine whether the problem in the central nervous system is primarily one of poor blood flow or one of impaired nerve cell functioning; and to try to identify biological markers prior to treatment that will identify patients who are more or less likely to respond to the study treatment.
Key facts
- Study ID
- NCT00037479
- Run by
- National Institute of Neurological Disorders and Stroke (NINDS)
- People needed
- 65
- Starts
- 1999-12-01
- Last updated by the study team
- 2005-12-07
Who can join
Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.
You may qualify if…
- Eligible participants must:
- Be 18-65 years old
- Have persistent problems with memory, verbal fluency, or attention after having contracted Lyme disease.
- Be able to travel to New York for 4-5 evaluations over the course of one year. Travel costs for participants in need may be partially or fully reimbursable.
- Have had a history of well-documented Lyme disease using the CDC's clinical criteria and a current positive IgG Western blot or PCR.
- Have received, at some point in the past at least 3 weeks of IV antibiotic therapy for Lyme disease.
You may not qualify if…
- Ineligible from participation are people with the following:
- Other major medical or neurologic problems
- Smoke more than 10 cigarettes a day
- Uncontrolled high blood pressure
- Allergy to ceftriaxone (Rocephin)
- History of marked cocaine abuse
- Twenty healthy subjects are also being sought for the study.
Where it is running
- Columbia Presbyterian Medical Center — New York, New York, United States
Full record on ClinicalTrials.gov
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