Evaluation of the Effect on Glucose Control of AC2993 in Patients With Type 2 Diabetes Mellitus

Completed · Phase 3 · Has a placebo group

Conditions studied: Diabetes Mellitus, Non-Insulin-Dependent

In brief

This is a multicenter, randomized, blinded, placebo-controlled study to assess the effects on glucose control of AC2993 as compared to placebo in patients with type 2 diabetes. Patients will be randomized into one of two AC2993 treatment arms or to placebo treatment and will continue with their required existing diabetes medications (metformin and a sulfonylurea) throughout the study.

Key facts

Study ID

NCT00035984

Run by

AstraZeneca

People needed

734

Starts

2002-05-01

Expected to finish

2003-08-01

Last updated by the study team

2015-02-24

Who can join

Age: 16 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects with Type 2 diabetes mellitus
• Treated with both metformin and a sulfonylurea at defined doses for at least 3 months prior to screening
• BMI= 27-45 kg/m2
• HbA1c value between 7.5% and 11%

You may not qualify if…

• Treated with oral anti-diabetic medications other than metformin and sulfonylurea within 3 months of screening
• Patients treated previously with AC2993
• Patients presently treated with insulin

Where it is running

• Parkway Medical Center — Birmingham, Alabama, United States
• Extended Arm Physicians/ Southern Drug — Montgomery, Alabama, United States
• Southern Drug Research Network — Tallassee, Alabama, United States
• First Care Family Doctors — Fayetteville, Arkansas, United States
• Physicians Group Research Clinic, LLC — Little Rock, Arkansas, United States
• Advanced Clinical Research Institute — Anaheim, California, United States
• East Bay Clinical Trial Center — Concord, California, United States
• Medical Group of Encino — Encino, California, United States
• Valley Research — Fresno, California, United States
• St. Joseph Heritage Healthcare — Fullerton, California, United States
• Whittier Institute for Diabetes — La Jolla, California, United States
• Richard Cherlin, M.D. — Los Gatos, California, United States
• Dr. Martinez Medical Clinic — Moreno Valley, California, United States
• Comprehensive Diabetes-Endocrine Medical Associates — Redwood City, California, United States
• Radiant Research-San Diego — San Diego, California, United States
• Veterans Medical Research Foundation — San Diego, California, United States
• Diablo Clinical Research — Walnut Creek, California, United States
• Creekside Endocrine Associates — Denver, Colorado, United States
• University of Colorado-Barbara Davis Center for Childhood Diabetes — Denver, Colorado, United States
• Medstar Clinical Research — Washington D.C., District of Columbia, United States
• George Washington University — Washington D.C., District of Columbia, United States
• Medical Research Unlimited — Aventura, Florida, United States
• Morton Plant Mease Health Care — Clearwater, Florida, United States
• Clinical Research of West Florida, Inc. — Clearwater, Florida, United States
• Pinnacle Research Group — Anniston, Alabama, United States

Full record on ClinicalTrials.gov

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