St. John's Wort Vs. Placebo in Obsessive-Compulsive Disorder.

Completed · Phase 2

Conditions studied: Obsessive Compulsive Disorder

In brief

The purpose of this study is to determine the effectiveness of St. John's Wort as compared to placebo (an inactive substance) in the treatment of outpatients with obsessive compulsive disorder.

Key facts

Study ID: NCT00035438
Run by: National Center for Complementary and Integrative Health (NCCIH)
People needed: 60
Starts: 2002-05-01
Expected to finish: 2003-09-01
Last updated by the study team: 2006-08-04

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

Female patients: at least 2 years post-menopausal, surgically sterile, or practicing a medically acceptable method of contraception.
Meets DSM-IV criteria for obsessive compulsive disorder

You may not qualify if…

Primary diagnosis of major depression, dysthymia, panic disorder, social phobia, schizophrenia, schizo-affective disorder, bipolar disorder, or PTSD
Substance abuse or dependence in the past 6 months
Vascular dementia or primary degenerative dementia of the Alzheimer's type
Treatment with MAOIs, TCAs, SSRIs, venlafaxine, nefazodone, remeron, citalopram, or bupropion within 14 days of first visit.
Fluoxetine within 5 weeks of first visit.
Failure to respond to at least two adequate antidepressant trials for obsessive compulsive disorder
Investigational drugs within 30 days of baseline
Known allergy or hypersensitivity to St. John's Wort
Currently in behavior therapy for obsessive compulsive disorder
ALL INQUIRIES WILL UNDERGO A PHONE SCREENING TO DETERMINE WHETHER THEY MEET ELIGIBLITY REQUIREMENTS.

Where it is running

University of Oklahoma Health Science Center — Oklahoma City, Oklahoma, United States
Dean Foundation — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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