St. John's Wort Versus Placebo in Social Phobia

Completed · Phase 2

Conditions studied: Phobic Disorders

In brief

The purpose of this study is to determine the effectiveness of St. John's Wort as compared to placebo (an inactive substance) in the treatment of outpatients with social phobia.

Key facts

Study ID

NCT00035412

Run by

National Center for Complementary and Integrative Health (NCCIH)

People needed

40

Starts

2001-12-01

Expected to finish

2004-08-01

Last updated by the study team

2006-08-18

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Female patients: at least 2 years post-menopausal, surgically sterile, or practicing a medically acceptable method of contraception.
• Meets DSM-IV criteria for Social Phobia, generalized subtype, lasting 12 months in duration (phone screening will determine)

You may not qualify if…

• Primary diagnosis of major depression, dysthymia, panic disorder, schizophrenia, schizo-affective disorder, bipolar disorder, or PTSD
• Substance abuse or dependence in the past 6 months
• Vascular dementia or primary degenerative dementia of the Alzheimer's type
• Treatment with MAOIs, TCAs, SSRIs, venlafaxine, nefazodone, remeron, citalopram, or bupropion within 14 days of first visit.
• Fluoxetine within 14 days of first visit.
• Failure to respond to at least two adequate antidepressant trials for social anxiety.
• Investigational drugs within 30 days of baseline
• Known allergy or hypersensitivity to St. John's Wort
• Currently in behavior therapy for Social Phobia
• ALL INQUIRIES WILL UNDERGO A PHONE SCREENING TO DETERMINE WHETHER THEY MEET ELIGIBLITY REQUIREMENTS.

Where it is running

• The Dean Foundation for Health, Research, and Education — Madison, Wisconsin, United States

Full record on ClinicalTrials.gov

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